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Recognizing Depression from the Microbiota-Gut-Brain Axis
Liang, Shan1; Wu, Xiaoli1,2; Hu, Xu1; Wang, Tao1; Jin, Feng1
Corresponding AuthorJin, Feng(jinfeng@psych.ac.cn)
AbstractMajor depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain-gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherapy. Unfortunately, most of the patients have never received any treatment. Studies indicate that gut microbiota could be a direct cause for the disorder. Abnormal microbiota and the microbiota-gut-brain dysfunction may cause mental disorders, while correcting these disturbance could alleviate depression. Nowadays, the gut microbiota modulation has become a hot topic in treatment research of mental disorders. Depression is closely related with the health condition of the brain-gut axis, and maintaining/restoring the normal condition of gut microbiota helps in the prevention/therapy of mental disorders.
Keywordmajor depressive disorder brain-gut axis microbiota-gut-brain axis gut microbiota psychobiotics
2018-06-01
Language英语
DOI10.3390/ijms19061592
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume19Issue:6Pages:16
Indexed BySCI
PublisherMDPI
WOS KeywordADULT HIPPOCAMPAL NEUROGENESIS ; IRRITABLE-BOWEL-SYNDROME ; PITUITARY-ADRENAL AXIS ; CENTRAL-NERVOUS-SYSTEM ; FECAL MICROBIOTA ; MATERNAL SEPARATION ; MAJOR DEPRESSION ; INTESTINAL MICROBIOTA ; PSYCHIATRIC-DISORDERS ; PROBIOTIC TREATMENT
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000436506600047
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30388
Collection中国科学院心理健康重点实验室
Corresponding AuthorJin, Feng
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liang, Shan,Wu, Xiaoli,Hu, Xu,et al. Recognizing Depression from the Microbiota-Gut-Brain Axis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(6):16.
APA Liang, Shan,Wu, Xiaoli,Hu, Xu,Wang, Tao,&Jin, Feng.(2018).Recognizing Depression from the Microbiota-Gut-Brain Axis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(6),16.
MLA Liang, Shan,et al."Recognizing Depression from the Microbiota-Gut-Brain Axis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.6(2018):16.
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