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The remediation effects of working memory training in schizophrenia patients with prominent negative symptoms
Li, Xu1,2,3; Chu, Min-yi4; Lv, Qin-yu5; Hu, Hui-xin4; Li, Zhi1,2; Yi, Zheng-hui5; Wang, Jin-hong6; Zhang, Jian-ye6; Lui, Simon S. Y.1,7; Cheung, Eric F. C.7; Shum, David H. K.1,8,9,10; Chan, Raymond C. K.1,2,4,8,9
First AuthorLi, Xu
2019-11-02
Source PublicationCOGNITIVE NEUROPSYCHIATRY
Correspondent Emailraymond c. k. chan rckchan@psych.ac.cn
ISSN1354-6805
SubtypeArticle
Volume24Issue:6Pages:434-453
Contribution Rank1
Abstract

Introduction: Negative symptoms, particularly amotivation and anhedonia, are important predictors of poor functional outcome in patients with schizophrenia. There has been interest in the efficacy and mechanism of non-pharmacological interventions to alleviate these symptoms. The present study aimed to examine the remediation effect of working memory (WM) training in patients with schizophrenia with prominent negative symptoms. Methods: Thirty-one schizophrenia patients with prominent negative symptoms were recruited and assigned to either a WM training group or a treatment-as-usual (TAU) control group. The WM training group underwent 20 sessions of training using the dual n-back task over one month. A functional neuroimaging paradigm of the Affective Incentive Delay (AID) task was administered before and after the training intervention to evaluate the remediation effect of the intervention. Results: Our results showed that the WM training group demonstrated significant improvement in the WM training task and inattention symptoms. Compared with the TAU group, increased brain activations were observed at the right insula and the right frontal sub-gyral after WM training in the training group. Conclusions: These findings support the efficacy of WM training in ameliorating hedonic dysfunction in schizophrenia patients with prominent negative symptoms.

KeywordDual n-back training hedonic processing anticipatory pleasure consummatory pleasure functional magnetic resonance imaging (fMRI)
DOI10.1080/13546805.2019.1674644
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Beijing Training Project for Leading Talents in ST ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Key Research and Development Programme ; Beijing Municipal Science and Technology Commission
Funding ProjectNational Natural Science Foundation of China[81571317] ; National Natural Science Foundation of China[31700957] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science and Technology Commission[Z161100000216138]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000498464100001
PublisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
WOS KeywordCOGNITIVE REMEDIATION ; INDIVIDUAL-DIFFERENCES ; PREFRONTAL CORTEX ; METAANALYSIS ; SCALE ; ANHEDONIA ; PLEASURE ; DEFICITS ; TASK ; ABNORMALITIES
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30452
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Cent China Normal Univ, Sch Psychol, Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan, Hubei, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Shanghai, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
6.Shanghai Mental Hlth Ctr, MRI Ctr, Shanghai, Peoples R China
7.Castle Peak Hosp, Hong Kong, Peoples R China
8.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia
9.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia
10.Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Li, Xu,Chu, Min-yi,Lv, Qin-yu,et al. The remediation effects of working memory training in schizophrenia patients with prominent negative symptoms[J]. COGNITIVE NEUROPSYCHIATRY,2019,24(6):434-453.
APA Li, Xu.,Chu, Min-yi.,Lv, Qin-yu.,Hu, Hui-xin.,Li, Zhi.,...&Chan, Raymond C. K..(2019).The remediation effects of working memory training in schizophrenia patients with prominent negative symptoms.COGNITIVE NEUROPSYCHIATRY,24(6),434-453.
MLA Li, Xu,et al."The remediation effects of working memory training in schizophrenia patients with prominent negative symptoms".COGNITIVE NEUROPSYCHIATRY 24.6(2019):434-453.
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