PSYCH OpenIR  > 中国科学院心理健康重点实验室
Association between the OXTR rs53576 genotype and latent profiles of post-traumatic stress disorder and depression symptoms in a representative sample of earthquake survivors
Cao, Chengqi1,2,3; Wang, Li2,3; Wu, Jianhui1; Li, Gen2,3; Fang, Ruojiao2,3; Liu, Ping4; Luo, Shu4; Elhai, Jon D.5,6
First AuthorCao, Chengqi
Correspondent Emailli wang wangli1@psych.ac.cn ; jianhui wu wujh8@szu.edu.cn
Contribution Rank2
Abstract

Background and Objectives: Post-traumatic stress disorder (PTSD) and major depressive disorder are commonly experienced mental disorders among psychological trauma victims. Few studies have investigated the genetic basis for population heterogeneity of trauma-related psychopathology, including PTSD and depression. This study examined the main and interaction effects of the OXTR rs53576 genotype in distinguishing four subgroups identified by symptom profiles of PTSD and depression symptoms using latent pro?le analysis. Design: A cross-sectional design with a gene-environment interaction approach was adopted in the current study. Methods: This study was a secondary data analysis conducted on a sample of 1196 adult earthquake survivors. Participants completed assessments of earthquake exposure, PTSD symptoms, and depression symptoms. The rs53576 polymorphism of OXTR was genotyped using a custom-by-design 2x48-Plex SNPscan(TM)Kit. Results: Multinomial logistic regression analyses revealed the main effects of the rs53576 genotype on symptom profiles. Specifically, G allele carriers were more likely in the combined PTSD-depression group than in the low symptom, predominantly depression, and predominantly PTSD groups. No significant interaction effects between this genotype and earthquake exposure on symptom profiles were found. Conclusions: Our findings support a genetic basis for trauma-related psychopathology heterogeneity. Furthermore, results provide preliminary evidence for the role of OXTR in PTSD/depression comorbidity.

KeywordPTSD depression population heterogeneity OXTR rs53576 association study
2019-11-28
Language英语
DOI10.1080/10615806.2019.1695604
Source PublicationANXIETY STRESS AND COPING
ISSN1061-5806
Pages8
Subtypearticle
Indexed BySCI
Funding ProjectKey Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4] ; National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31971020] ; National Natural Science Foundation of China[31771246] ; China Postdoctoral Science Foundation[2018M633141] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036]
PublisherTAYLOR & FRANCIS LTD
WOS KeywordRECEPTOR GENE OXTR ; MENTAL-HEALTH ; OXYTOCIN ; POLYMORPHISM ; MALTREATMENT ; SENSITIVITY ; INTERPLAY ; GENOMICS ; TRAUMA ; LIFE
WOS Research AreaNeurosciences & Neurology ; Psychiatry ; Psychology
WOS SubjectNeurosciences ; Psychiatry ; Psychology, Multidisciplinary
WOS IDWOS:000498779800001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30464
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Li; Wu, Jianhui
Affiliation1.Shenzhen Univ, Ctr Brain Disorder & Cognit Sci, Shenzhen, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Peoples Hosp Deyang City, Deyang, Peoples R China
5.Univ Toledo, Dept Psychol, Toledo, OH 43606 USA
6.Univ Toledo, Dept Psychiat, Toledo, OH USA
Recommended Citation
GB/T 7714
Cao, Chengqi,Wang, Li,Wu, Jianhui,et al. Association between the OXTR rs53576 genotype and latent profiles of post-traumatic stress disorder and depression symptoms in a representative sample of earthquake survivors[J]. ANXIETY STRESS AND COPING,2019:8.
APA Cao, Chengqi.,Wang, Li.,Wu, Jianhui.,Li, Gen.,Fang, Ruojiao.,...&Elhai, Jon D..(2019).Association between the OXTR rs53576 genotype and latent profiles of post-traumatic stress disorder and depression symptoms in a representative sample of earthquake survivors.ANXIETY STRESS AND COPING,8.
MLA Cao, Chengqi,et al."Association between the OXTR rs53576 genotype and latent profiles of post-traumatic stress disorder and depression symptoms in a representative sample of earthquake survivors".ANXIETY STRESS AND COPING (2019):8.
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