Institutional Repository of Key Laboratory of Mental Health, CAS
Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder | |
Liu, Jin1,2; Dong, Qiangli1,2; Lu, Xiaowen1,2; Sun, Jinrong1,2; Zhang, Liang1,2; Wang, Mi1,2; Wan, Ping3; Guo, Hua3; Zhao, Futao3; Ju, Yumeng1,2; Yan, Danfeng1,2; Li, Haolun1,2; Fang, Han1,2; Guo, Weilong1,2; Liao, Mei1,2; Zhang, Xiangyang4; Zhang, Yan1,2; Liu, Bangshan1,2; Li, Lingjiang1,2 | |
第一作者 | Liu, Jin |
通讯作者邮箱 | bangshan liu bangshan.liu@csu.edu.cn ; lingjiang li llj2920@163.com |
心理所单位排序 | 4 |
摘要 | Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be a major cognitive deficit independently caused by depression at acute episodes of MDD. Method: A comprehensive neurocognitive test battery was used to assess the executive function, processing speed, attention, and memory in 162 MDD patients and 142 healthy controls (HCs). A multivariate analysis of variance, hierarchical regression analyses and general linear regression analyses were used to explore the possible major cognitive deficits and their predictor variables. Results: MDD patients showed extensive impairment in all four cognitive domains. Impairment of executive function and processing speed were found to persist even with other cognitive domains and clinical variables being accounted for. Executive function and processing speed were further predicted by total disease duration and depression severity, respectively. Conclusions: Executive function and processing speed may be two distinct major deficits at acute episodes of MDD. Furthermore, the executive function is likely originated from the cumulative effect of disease duration and processing speed is possibly derived from the temporary effect of current depressive episode. |
关键词 | depression cognitive function neurocognition executive function processing speed |
2019-11-12 | |
语种 | 英语 |
DOI | 10.3389/fpsyt.2019.00836 |
发表期刊 | FRONTIERS IN PSYCHIATRY |
ISSN | 1664-0640 |
卷号 | 10页码:8 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Science and Technologic Program of China[2015BAI13B02] ; Defense Innovative Special Region Program[17-163-17-XZ-004-00501] ; National Natural Science Foundation of China[81171286] ; National Natural Science Foundation of China[91232714] ; National Natural Science Foundation of China[81601180] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | LATE-LIFE DEPRESSION ; EXECUTIVE FUNCTION ; BRAIN MORPHOLOGY ; IMPAIRMENT ; DYSFUNCTION ; REMISSION ; DETERMINANTS ; METAANALYSIS ; RETARDATION ; ASSOCIATION |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000499225900001 |
资助机构 | National Science and Technologic Program of China ; Defense Innovative Special Region Program ; National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30486 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Liu, Bangshan; Li, Lingjiang |
作者单位 | 1.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China 2.Cent S Univ, China Natl Clin Res Ctr Mental Disorders Xiangya, China Natl Technol Inst Mental Disorders,Mental H, Hunan Technol Inst Psychiat,Hunan Key Lab Psychia, Changsha, Hunan, Peoples R China 3.Zhumadian Psychiat Hosp, Dept Psychiat, Zhumadian, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Jin,Dong, Qiangli,Lu, Xiaowen,et al. Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2019,10:8. |
APA | Liu, Jin.,Dong, Qiangli.,Lu, Xiaowen.,Sun, Jinrong.,Zhang, Liang.,...&Li, Lingjiang.(2019).Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,10,8. |
MLA | Liu, Jin,et al."Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 10(2019):8. |
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