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Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder
Liu, Jin1,2; Dong, Qiangli1,2; Lu, Xiaowen1,2; Sun, Jinrong1,2; Zhang, Liang1,2; Wang, Mi1,2; Wan, Ping3; Guo, Hua3; Zhao, Futao3; Ju, Yumeng1,2; Yan, Danfeng1,2; Li, Haolun1,2; Fang, Han1,2; Guo, Weilong1,2; Liao, Mei1,2; Zhang, Xiangyang4; Zhang, Yan1,2; Liu, Bangshan1,2; Li, Lingjiang1,2
First AuthorLiu, Jin
Correspondent Emailbangshan liu bangshan.liu@csu.edu.cn ; lingjiang li llj2920@163.com
2019-11-12
Source PublicationFRONTIERS IN PSYCHIATRY
ISSN1664-0640
Subtypearticle
Volume10Pages:8
Contribution Rank4
Abstract

Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be a major cognitive deficit independently caused by depression at acute episodes of MDD. Method: A comprehensive neurocognitive test battery was used to assess the executive function, processing speed, attention, and memory in 162 MDD patients and 142 healthy controls (HCs). A multivariate analysis of variance, hierarchical regression analyses and general linear regression analyses were used to explore the possible major cognitive deficits and their predictor variables. Results: MDD patients showed extensive impairment in all four cognitive domains. Impairment of executive function and processing speed were found to persist even with other cognitive domains and clinical variables being accounted for. Executive function and processing speed were further predicted by total disease duration and depression severity, respectively. Conclusions: Executive function and processing speed may be two distinct major deficits at acute episodes of MDD. Furthermore, the executive function is likely originated from the cumulative effect of disease duration and processing speed is possibly derived from the temporary effect of current depressive episode.

Keyworddepression cognitive function neurocognition executive function processing speed
DOI10.3389/fpsyt.2019.00836
Indexed BySCI
Language英语
Funding OrganizationNational Science and Technologic Program of China ; Defense Innovative Special Region Program ; National Natural Science Foundation of China
Funding ProjectNational Science and Technologic Program of China[2015BAI13B02] ; Defense Innovative Special Region Program[17-163-17-XZ-004-00501] ; National Natural Science Foundation of China[81171286] ; National Natural Science Foundation of China[91232714] ; National Natural Science Foundation of China[81601180]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000499225900001
PublisherFRONTIERS MEDIA SA
WOS KeywordLATE-LIFE DEPRESSION ; EXECUTIVE FUNCTION ; BRAIN MORPHOLOGY ; IMPAIRMENT ; DYSFUNCTION ; REMISSION ; DETERMINANTS ; METAANALYSIS ; RETARDATION ; ASSOCIATION
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30486
Collection中国科学院心理健康重点实验室
Corresponding AuthorLiu, Bangshan; Li, Lingjiang
Affiliation1.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China
2.Cent S Univ, China Natl Clin Res Ctr Mental Disorders Xiangya, China Natl Technol Inst Mental Disorders,Mental H, Hunan Technol Inst Psychiat,Hunan Key Lab Psychia, Changsha, Hunan, Peoples R China
3.Zhumadian Psychiat Hosp, Dept Psychiat, Zhumadian, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jin,Dong, Qiangli,Lu, Xiaowen,et al. Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2019,10:8.
APA Liu, Jin.,Dong, Qiangli.,Lu, Xiaowen.,Sun, Jinrong.,Zhang, Liang.,...&Li, Lingjiang.(2019).Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,10,8.
MLA Liu, Jin,et al."Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 10(2019):8.
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