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Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder | |
Liu, Jin1,2; Dong, Qiangli1,2; Lu, Xiaowen1,2; Sun, Jinrong1,2; Zhang, Liang1,2![]() ![]() | |
First Author | Liu, Jin |
Correspondent Email | bangshan liu bangshan.liu@csu.edu.cn ; lingjiang li llj2920@163.com |
Contribution Rank | 4 |
Abstract | Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be a major cognitive deficit independently caused by depression at acute episodes of MDD. Method: A comprehensive neurocognitive test battery was used to assess the executive function, processing speed, attention, and memory in 162 MDD patients and 142 healthy controls (HCs). A multivariate analysis of variance, hierarchical regression analyses and general linear regression analyses were used to explore the possible major cognitive deficits and their predictor variables. Results: MDD patients showed extensive impairment in all four cognitive domains. Impairment of executive function and processing speed were found to persist even with other cognitive domains and clinical variables being accounted for. Executive function and processing speed were further predicted by total disease duration and depression severity, respectively. Conclusions: Executive function and processing speed may be two distinct major deficits at acute episodes of MDD. Furthermore, the executive function is likely originated from the cumulative effect of disease duration and processing speed is possibly derived from the temporary effect of current depressive episode. |
Keyword | depression cognitive function neurocognition executive function processing speed |
2019-11-12 | |
Language | 英语 |
DOI | 10.3389/fpsyt.2019.00836 |
Source Publication | FRONTIERS IN PSYCHIATRY
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ISSN | 1664-0640 |
Volume | 10Pages:8 |
Subtype | article |
Indexed By | SCI |
Funding Project | National Science and Technologic Program of China[2015BAI13B02] ; Defense Innovative Special Region Program[17-163-17-XZ-004-00501] ; National Natural Science Foundation of China[81171286] ; National Natural Science Foundation of China[91232714] ; National Natural Science Foundation of China[81601180] |
Publisher | FRONTIERS MEDIA SA |
WOS Keyword | LATE-LIFE DEPRESSION ; EXECUTIVE FUNCTION ; BRAIN MORPHOLOGY ; IMPAIRMENT ; DYSFUNCTION ; REMISSION ; DETERMINANTS ; METAANALYSIS ; RETARDATION ; ASSOCIATION |
WOS Research Area | Psychiatry |
WOS Subject | Psychiatry |
WOS ID | WOS:000499225900001 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/30486 |
Collection | 中国科学院心理健康重点实验室 |
Corresponding Author | Liu, Bangshan; Li, Lingjiang |
Affiliation | 1.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China 2.Cent S Univ, China Natl Clin Res Ctr Mental Disorders Xiangya, China Natl Technol Inst Mental Disorders,Mental H, Hunan Technol Inst Psychiat,Hunan Key Lab Psychia, Changsha, Hunan, Peoples R China 3.Zhumadian Psychiat Hosp, Dept Psychiat, Zhumadian, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
Recommended Citation GB/T 7714 | Liu, Jin,Dong, Qiangli,Lu, Xiaowen,et al. Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2019,10:8. |
APA | Liu, Jin.,Dong, Qiangli.,Lu, Xiaowen.,Sun, Jinrong.,Zhang, Liang.,...&Li, Lingjiang.(2019).Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,10,8. |
MLA | Liu, Jin,et al."Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 10(2019):8. |
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Exploration of Major(808KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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