Institutional Repository of Key Laboratory of Behavioral Science, CAS
Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study | |
Qi, Zhigang1,2; An, Yanhong1,2; Zhang, Mo1,2; Li, Hui-Jie3; Lu, Jie1,2 | |
第一作者 | Qi, Zhigang |
通讯作者邮箱 | hui-jie li lihj@psych.ac.cn ; jie lu imaginglu@hotmail.com |
心理所单位排序 | 3 |
摘要 | Recent evidence suggests that the cerebellum is related to motor and non-motor cognitive functions, and that several coupled cerebro-cerebellar networks exist, including links with the limbic network. Since several limbic structures are affected by Alzheimer pathology, even in the preclinical stages of Alzheimer's disease (AD), we aimed to investigate the cerebral limbic network activity from the perspective of the cerebellum. Twenty patients with mild cognitive impairment (MCI), 18 patients with AD, and 26 healthy controls (HC) were recruited to acquire Resting-state functional MRI (rs-fMRI). We used seed-based approach to construct the cerebro-cerebellar limbic network. Two-sample t-tests were carried out to explore the differences of the cerebellar limbic network connectivity. The first result, a sub-scale network including the bilateral posterior part of the orbitofrontal cortex (POFC) extending to the anterior insular cortex (AIC) and left inferior parietal lobule (L-IPL), showed greater functional connectivity in MCI than in HC and less functional connectivity in AD than in MCI. The location of this sub-scale network was in accordance with components of the ventral attention network. Second, there was decreased functional connectivity to the right mid-cingulate cortex (MCC) in the AD and MCI patient groups relative to the HC group. As the cerebellum is not compromised by Alzheimer pathology in the prodromal stage of AD, this pattern indicates that the sub-scale ventral attention network may play a pivotal role in functional compensation through the coupled cerebro-cerebellar limbic network in MCI, and the cerebellum may be a key node in the modulation of social cognition. |
关键词 | mild cognitive impairment Alzheimer's disease cerebro-cerebellar connectivity limbic network resting-state functional MRI compensation |
2019-11-06 | |
语种 | 英语 |
DOI | 10.3389/fncir.2019.00072 |
发表期刊 | FRONTIERS IN NEURAL CIRCUITS |
卷号 | 13页码:9 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | Beijing Municipal Geriatric Medical Research Center Project[PXM2019_026283_000003] ; Beijing Municipal Commission of Science and Technology[Z171100000117001] ; Beijing Municipal Administration of Hospitals' Ascent Plan[DFL20180802] ; Natural Science Foundation of China[81141018] ; Natural Science Foundation of China[31871143] ; National Key Research and Development Program of China[2016YFC0107100] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | MILD COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; NEUROPSYCHIATRIC SYMPTOMS ; PARIETAL CORTEX ; AMYLOID-BETA ; CEREBELLUM ; MEMORY ; DISTINCT ; EMOTION |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000498208800001 |
Q分类 | Q2 |
资助机构 | Beijing Municipal Geriatric Medical Research Center Project ; Beijing Municipal Commission of Science and Technology ; Beijing Municipal Administration of Hospitals' Ascent Plan ; Natural Science Foundation of China ; National Key Research and Development Program of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30501 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Li, Hui-Jie; Lu, Jie |
作者单位 | 1.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China 2.Beijing Key Lab Magnet Resonance Imaging & Brain, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Qi, Zhigang,An, Yanhong,Zhang, Mo,et al. Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study[J]. FRONTIERS IN NEURAL CIRCUITS,2019,13:9. |
APA | Qi, Zhigang,An, Yanhong,Zhang, Mo,Li, Hui-Jie,&Lu, Jie.(2019).Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study.FRONTIERS IN NEURAL CIRCUITS,13,9. |
MLA | Qi, Zhigang,et al."Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study".FRONTIERS IN NEURAL CIRCUITS 13(2019):9. |
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