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Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study
Qi, Zhigang1,2; An, Yanhong1,2; Zhang, Mo1,2; Li, Hui-Jie3; Lu, Jie1,2
First AuthorQi, Zhigang
Correspondent Emailhui-jie li lihj@psych.ac.cn ; jie lu imaginglu@hotmail.com
Contribution Rank3
Abstract

Recent evidence suggests that the cerebellum is related to motor and non-motor cognitive functions, and that several coupled cerebro-cerebellar networks exist, including links with the limbic network. Since several limbic structures are affected by Alzheimer pathology, even in the preclinical stages of Alzheimer's disease (AD), we aimed to investigate the cerebral limbic network activity from the perspective of the cerebellum. Twenty patients with mild cognitive impairment (MCI), 18 patients with AD, and 26 healthy controls (HC) were recruited to acquire Resting-state functional MRI (rs-fMRI). We used seed-based approach to construct the cerebro-cerebellar limbic network. Two-sample t-tests were carried out to explore the differences of the cerebellar limbic network connectivity. The first result, a sub-scale network including the bilateral posterior part of the orbitofrontal cortex (POFC) extending to the anterior insular cortex (AIC) and left inferior parietal lobule (L-IPL), showed greater functional connectivity in MCI than in HC and less functional connectivity in AD than in MCI. The location of this sub-scale network was in accordance with components of the ventral attention network. Second, there was decreased functional connectivity to the right mid-cingulate cortex (MCC) in the AD and MCI patient groups relative to the HC group. As the cerebellum is not compromised by Alzheimer pathology in the prodromal stage of AD, this pattern indicates that the sub-scale ventral attention network may play a pivotal role in functional compensation through the coupled cerebro-cerebellar limbic network in MCI, and the cerebellum may be a key node in the modulation of social cognition.

Keywordmild cognitive impairment Alzheimer's disease cerebro-cerebellar connectivity limbic network resting-state functional MRI compensation
2019-11-06
Language英语
DOI10.3389/fncir.2019.00072
Source PublicationFRONTIERS IN NEURAL CIRCUITS
Volume13Pages:9
Subtypearticle
Indexed BySCI
Funding ProjectBeijing Municipal Geriatric Medical Research Center Project[PXM2019_026283_000003] ; Beijing Municipal Commission of Science and Technology[Z171100000117001] ; Beijing Municipal Administration of Hospitals' Ascent Plan[DFL20180802] ; Natural Science Foundation of China[81141018] ; Natural Science Foundation of China[31871143] ; National Key Research and Development Program of China[2016YFC0107100]
PublisherFRONTIERS MEDIA SA
WOS KeywordMILD COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; NEUROPSYCHIATRIC SYMPTOMS ; PARIETAL CORTEX ; AMYLOID-BETA ; CEREBELLUM ; MEMORY ; DISTINCT ; EMOTION
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000498208800001
QuartileQ2
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30501
Collection中国科学院行为科学重点实验室
Corresponding AuthorLi, Hui-Jie; Lu, Jie
Affiliation1.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
2.Beijing Key Lab Magnet Resonance Imaging & Brain, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Qi, Zhigang,An, Yanhong,Zhang, Mo,et al. Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study[J]. FRONTIERS IN NEURAL CIRCUITS,2019,13:9.
APA Qi, Zhigang,An, Yanhong,Zhang, Mo,Li, Hui-Jie,&Lu, Jie.(2019).Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study.FRONTIERS IN NEURAL CIRCUITS,13,9.
MLA Qi, Zhigang,et al."Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study".FRONTIERS IN NEURAL CIRCUITS 13(2019):9.
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