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Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study
Hui, Li1,2,3,4; Yin, Xiao Li2; Chen, Jie1; Yin, Xu Yuan1; Zhu, Hong Liang1; Li, Jin1; Yin, Guang Zhong1; Xu, Xiao Wen1; Yang, Xiao Nan1; Qian, Zheng Kang1; Jiang, Cai Xia1; Tang, Zhen1; Yang, Hai Bing4; Cheung, Eric F. C.5; Chan, Raymond C. K.3,6,7; Jia, Qiu Fang1,4
2019-12-01
Source PublicationINTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
ISSN2194-7511
Volume7Issue:1Pages:7
Abstract

Background Cognitive deficits are common in patients with bipolar disorder (BD). Abnormal high density lipoprotein (HDL) levels have been implicated in cognitive deficits associated with ageing and neurodegenerative disorders. The present study aimed to investigate serum HDL levels, cognitive deficits and their association in patients with BD. Methods Thirty-seven patients with BD and 37 gender- and age-matched healthy controls (HCs) were recruited in a case-control study. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and serum HDL levels were measured using enzymatic colourimetry. Results There was no difference in serum HDL levels between patients with BD and HCs after adjusting for gender, age, education and body mass index (BMI). Cognitive test scores in patients with BD were significantly lower than those in HCs except for the visuospatial/constructional index after adjusting for confounding variables. Serum HDL levels were positively correlated with RBANS total score and language score in patients with BD. Stepwise multiple regression analysis showed that serum HDL levels were significantly correlated with RBANS total score and subscale scores on immediate memory and language in patients with BD after adjusting for confounding factors. Conclusions Our findings suggest that patients with BD had poorer cognitive performance than HCs except for the visuospatial/constructional domain, and decreased serum HDL levels were correlated with cognitive deficits, especially in immediate memory and language domains in patients with BD.

KeywordHigh density lipoprotein Bipolar disorder Cognition RBANS
DOI10.1186/s40345-019-0159-7
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Jiangsu High-level Health Talent Project ; Jiangsu Six Talent Peaks Project ; Jiangsu Key Research and Development Program ; Suzhou Medical Key Subject ; Suzhou Key Diagnosis and Treatment Program ; Suzhou Key Laboratory for Biological Psychiatry ; Suzhou Key Medical Center for Psychiatric Diseases ; Suzhou Sci-Tech Bureau Program ; Suzhou Health City 531 Action Plan ; Zhejiang Province Rising Star in Medicine ; CAS Key Laboratory of Mental Health, Institute of Psychology
Funding ProjectNational Natural Science Foundation of China[81771439] ; National Natural Science Foundation of China[81501160] ; Jiangsu High-level Health Talent Project[LGY2018010] ; Jiangsu High-level Health Talent Project[QNRC2016228] ; Jiangsu Six Talent Peaks Project[WSN-165] ; Jiangsu Key Research and Development Program[BE2018662] ; Suzhou Medical Key Subject[Szxk201815] ; Suzhou Medical Key Subject[Szxk201515] ; Suzhou Key Diagnosis and Treatment Program[LCZX201820] ; Suzhou Key Diagnosis and Treatment Program[LCZX201615] ; Suzhou Key Diagnosis and Treatment Program[LCZX201515] ; Suzhou Key Laboratory for Biological Psychiatry[SZS201722] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Sci-Tech Bureau Program[SS201706] ; Suzhou Sci-Tech Bureau Program[SYS201578] ; Suzhou Health City 531 Action Plan ; Zhejiang Province Rising Star in Medicine ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K03]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000500395200001
PublisherSPRINGEROPEN
WOS KeywordHIGH-DENSITY-LIPOPROTEIN ; APOLIPOPROTEIN-A-I ; NEUROPSYCHOLOGICAL STATUS RBANS ; REPEATABLE BATTERY ; 1ST-DEGREE RELATIVES ; EUTHYMIC PATIENTS ; MOUSE MODEL ; CHOLESTEROL ; SCHIZOPHRENIA ; PERFORMANCE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30517
Collection中国科学院心理健康重点实验室
Corresponding AuthorHui, Li; Chan, Raymond C. K.; Jia, Qiu Fang
Affiliation1.Soochow Univ, Affiliated Guangji Hosp, Suzhou Guangji Hosp, Inst Mental Hlth, 11 Guangqian Rd, Suzhou 215137, Jiangsu, Peoples R China
2.Wenzhou Med Univ, Wenzhou Kangning Hosp, Wenzhou, Zhejiang, Peoples R China
3.Inst Psychiat, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Suzhou Ctr Dis Control & Prevent, Suzhou, Jiangsu, Peoples R China
5.Castle Peak Hosp, Hong Kong, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Hui, Li,Yin, Xiao Li,Chen, Jie,et al. Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study[J]. INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS,2019,7(1):7.
APA Hui, Li.,Yin, Xiao Li.,Chen, Jie.,Yin, Xu Yuan.,Zhu, Hong Liang.,...&Jia, Qiu Fang.(2019).Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study.INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS,7(1),7.
MLA Hui, Li,et al."Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study".INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS 7.1(2019):7.
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