Institutional Repository of Key Laboratory of Mental Health, CAS
Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats | |
Liu, Xinhe1,2; Wang, Ning1,2; Wang, Jinyan1,2; Luo, Fei1,2 | |
第一作者 | Liu, Xinhe |
通讯作者邮箱 | wangn@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Time perception is an important ability that is related closely to humans' and animals' daily activities. It can be distorted by various emotional states. In human studies, experimental pain has been shown to prolong the perception of time. However, related animal studies are lacking. In this study, we used a temporal bisection task to investigate how acute inflammatory pain (induced by hind-paw formalin injection) and chronic neuropathic pain [induced by spinal nerve ligation (SNL)] affected time perception in rats. Rats were trained to recognize "short" (1200-ms) and "long" (2400-ms) anchor-duration pure tones and were rewarded for corresponding lever presses. During testing, rats perceived a series of intermediate-duration and anchor-duration pure tones, and selected levers corresponding to the "short" and "long" tones. After formalin injection, rats gave more "long" lever-press responses than after saline injection. The point of subjective equality after formalin injection also increased, suggesting that formalin-induced acute pain extended time perception. In contrast, rats that had undergone SNL gave fewer "long" lever-press responses compared with the sham surgery group. This animal study suggests that formalin-induced pain and neuropathic pain may have different effects on time perception. |
2019-12-10 | |
语种 | 英语 |
DOI | 10.1038/s41598-019-55168-w |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 9页码:11 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | INFLAMMATORY PAIN ; NORADRENERGIC MODULATION ; PREFRONTAL CORTEX ; INTERNAL CLOCK ; PERCEPTION ; DEPRESSION ; ATTENTION ; DISCRIMINATION ; MECHANISMS ; BEHAVIOR |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000501991200001 |
WOS分区 | Q1 |
资助机构 | NNSF (National Natural Science Foundation of China) ; NNSF ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Program for Creative Research Teams |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30523 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Ning |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Xinhe,Wang, Ning,Wang, Jinyan,et al. Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats[J]. SCIENTIFIC REPORTS,2019,9:11. |
APA | Liu, Xinhe,Wang, Ning,Wang, Jinyan,&Luo, Fei.(2019).Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats.SCIENTIFIC REPORTS,9,11. |
MLA | Liu, Xinhe,et al."Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats".SCIENTIFIC REPORTS 9(2019):11. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Formalin-induced and(2468KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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