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Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats
Liu, Xinhe1,2; Wang, Ning1,2; Wang, Jinyan1,2; Luo, Fei1,2
First AuthorLiu, Xinhe
Correspondent Emailwangn@psych.ac.cn
2019-12-10
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Subtypearticle
Volume9Pages:11
Contribution Rank1
Abstract

Time perception is an important ability that is related closely to humans' and animals' daily activities. It can be distorted by various emotional states. In human studies, experimental pain has been shown to prolong the perception of time. However, related animal studies are lacking. In this study, we used a temporal bisection task to investigate how acute inflammatory pain (induced by hind-paw formalin injection) and chronic neuropathic pain [induced by spinal nerve ligation (SNL)] affected time perception in rats. Rats were trained to recognize "short" (1200-ms) and "long" (2400-ms) anchor-duration pure tones and were rewarded for corresponding lever presses. During testing, rats perceived a series of intermediate-duration and anchor-duration pure tones, and selected levers corresponding to the "short" and "long" tones. After formalin injection, rats gave more "long" lever-press responses than after saline injection. The point of subjective equality after formalin injection also increased, suggesting that formalin-induced acute pain extended time perception. In contrast, rats that had undergone SNL gave fewer "long" lever-press responses compared with the sham surgery group. This animal study suggests that formalin-induced pain and neuropathic pain may have different effects on time perception.

DOI10.1038/s41598-019-55168-w
Indexed BySCI
Language英语
Funding OrganizationNNSF (National Natural Science Foundation of China) ; NNSF ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Program for Creative Research Teams
Funding ProjectNNSF (National Natural Science Foundation of China)[31671140] ; NNSF[31271092] ; NNSF[31471061] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH 2014G01] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016K02] ; CAS/SAFEA International Partnership Program for Creative Research Teams[Y2CX131003]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000501991200001
PublisherNATURE PUBLISHING GROUP
WOS KeywordINFLAMMATORY PAIN ; NORADRENERGIC MODULATION ; PREFRONTAL CORTEX ; INTERNAL CLOCK ; PERCEPTION ; DEPRESSION ; ATTENTION ; DISCRIMINATION ; MECHANISMS ; BEHAVIOR
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30523
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Ning
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xinhe,Wang, Ning,Wang, Jinyan,et al. Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats[J]. SCIENTIFIC REPORTS,2019,9:11.
APA Liu, Xinhe,Wang, Ning,Wang, Jinyan,&Luo, Fei.(2019).Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats.SCIENTIFIC REPORTS,9,11.
MLA Liu, Xinhe,et al."Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats".SCIENTIFIC REPORTS 9(2019):11.
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