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The effect of traumatic-like stress exposure on alterations in the temporal social behavior of a rodent population
Han, Mengfei1,2,3; Luo, Haoshuang2,3; Bai, Yunjing2,3; Zheng, Shichun2,3; Li, Fenghua2,3; Fu, Juan4; Jiang, Shaofei2,3; Liu, Zhengkui2,3; Zheng, Xigeng2,3
First AuthorHan, Mengfei
Correspondent Emailzhengxg@psych.ac.cn
Contribution Rank2
Abstract

Though the relationship between traumatic stress and social behavior, which has been explored for years, is dynamic and largely estimated between dyads, little is known about the causal effects of traumatic stress exposure on the time-dependent dynamic alterations in the social behaviors on a large-group level. We thus investigated the effect of a single prolonged stress (SPS) exposure, a classical animal model that recapitulates posttraumatic stress disorder (PTSD)-like symptoms in rodents, on the spatiotemporal, social behavior changes within a large group of cohabiting rats. One-half of thirty-two Sprague-Dawley rats were assigned to the experimental group and subjected to SPS treatment administered two weeks after baseline social behavior recording; the other half served as the controls. Each group of rats (n = 16) was housed in one of two large custom-made cylinders. We used an automatic tracking system to record the behavioral indices of social behavior of the rats before SPS exposure, on the SPS exposure day, during a 7-day-long quiescent period after SPS treatment, as well as during subsequent behavioral test days. In addition to SPS-induced PTSD-like behaviors, SPS induced a time-dependent, oscillating change in active/passive social behaviors that lasted for 3 weeks. SPS treatment decreased active social behaviors (especially affiliative behaviors) but increased passive social behaviors (e.g. huddling) immediately following stress exposure. Increased active social interactions were observed during the early phase after SPS treatment; while increased passive social behaviors were observed during the late phase after SPS treatment. These dynamic changes were repeatedly observed when the rats underwent subsequent stressful behavioral tests and challenges. SPS induced a long-term, time-dependent oscillating change in indices of the social behavior. These changes may serve as an adaptive mechanism, and their manifestations critically depended on the time course following the traumatic stress exposure.

KeywordPosttraumatic stress disorder single prolonged stress rat social behavior spatiotemporal active social interaction passive social interaction
2019-12-16
Language英语
DOI10.1080/10253890.2019.1702642
Source PublicationSTRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
ISSN1025-3890
Pages12
Subtypearticle
Indexed BySCI
Funding ProjectEvaluation and Intervention Technology Research for Posttraumatic Stress Patients Population[JCYJ20170413170301569] ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program[TSS-2015-06] ; CAS Key Laboratory of Mental Health, Institute of Psychology
PublisherTAYLOR & FRANCIS LTD
WOS KeywordSINGLE-PROLONGED STRESS ; SUCROSE PREFERENCE ; MODEL ; RATS ; SYMPTOMS ; PTSD ; FEAR ; EXPLORATION ; DEPRESSION ; RESPONSES
WOS Research AreaBehavioral Sciences ; Endocrinology & Metabolism ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Endocrinology & Metabolism ; Neurosciences
WOS IDWOS:000503317900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30538
Collection中国科学院心理健康重点实验室
Corresponding AuthorZheng, Xigeng
Affiliation1.Beijing Sport Univ, Sch Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Binzhou Univ, Coll Biol & Environm Engn, Binzhou, Shandong, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Han, Mengfei,Luo, Haoshuang,Bai, Yunjing,et al. The effect of traumatic-like stress exposure on alterations in the temporal social behavior of a rodent population[J]. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,2019:12.
APA Han, Mengfei.,Luo, Haoshuang.,Bai, Yunjing.,Zheng, Shichun.,Li, Fenghua.,...&Zheng, Xigeng.(2019).The effect of traumatic-like stress exposure on alterations in the temporal social behavior of a rodent population.STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,12.
MLA Han, Mengfei,et al."The effect of traumatic-like stress exposure on alterations in the temporal social behavior of a rodent population".STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2019):12.
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