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Neurochondrin Antibody Serum Positivity in Three Cases of Autoimmune Cerebellar Ataxia | |
Zhang Weihua1; Ren Haitao2; Fang Fang1; Yang Xunzhe2; Wang Jing3,4; Guan Hongzhi2 | |
第一作者 | Zhang Weihua |
通讯作者邮箱 | guan hongzhi pumchghz@126.com |
心理所单位排序 | 3 |
摘要 | To report three cases of autoimmune ataxia patients with positive neurochondrin (NCDN) antibodies. Patients with unknown cerebellar ataxia were screened for autoimmune cerebellar ataxia (ACA)-related antibodies, including glutamic acid decarboxylase 65 (GAD65), delta/notch-like epidermal growth factor-related receptor (Tr/DNER), zinc finger protein 4 (ZIC4), inositol 1,4,5-triphosphate receptor 1 (ITPR1), Homer protein homologue 3 (Homer-3), neurochondrin (NCDN), Purkinje cell antibody 2 (PCA-2) and carbonic anhydrase-related protein VII (CARPVII). The antibodies were assessed by indirect immunofluorescence using transfected cells (cell-based assay, CBA) and monkey cerebellum (tissue-based assay, TBA) with the multi-antigen co-plate biochip mosaic technique. Patients with positive antibodies received immunotherapy and were followed up in the clinic. Clinical characteristics, laboratory data, and outcomes of antibody-positive patients were described, analysed and compared with previously reported cases. The NCDN antibody was positive in three male patients in whom the onset ages were four years and 11 months, two years and seven months and 67 years old. Serum antibody titres were 1:32, 1:100 and 1:320. Cerebral ataxia was the most prominent presentation. Cerebellar atrophy was found in one of the patients. Immunotherapy was effective in all three patients. The NCDN antibody is associated with autoimmune ataxia, and it has been suggested that the NCDN antibody should be tested in patients with cerebellar ataxia who are negative for routine ACA antibodies. Early immunotherapy may have a beneficial impact on prognosis. |
关键词 | Neurochondrin NCDN Autoimmune Cerebellar Ataxia |
2019-12-01 | |
语种 | 英语 |
DOI | 10.1007/s12311-019-01048-y |
发表期刊 | CEREBELLUM |
ISSN | 1473-4222 |
卷号 | 18期号:6页码:1137-1142 |
期刊论文类型 | article |
收录类别 | SCI |
出版者 | SPRINGER |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000502725000010 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30573 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Guan Hongzhi |
作者单位 | 1.Capital Med Univ, Beijing Childrens Hosp, Dept Neurol, Natl Ctr Childrens Hlth, Beijing, Peoples R China 2.Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang Weihua,Ren Haitao,Fang Fang,et al. Neurochondrin Antibody Serum Positivity in Three Cases of Autoimmune Cerebellar Ataxia[J]. CEREBELLUM,2019,18(6):1137-1142. |
APA | Zhang Weihua,Ren Haitao,Fang Fang,Yang Xunzhe,Wang Jing,&Guan Hongzhi.(2019).Neurochondrin Antibody Serum Positivity in Three Cases of Autoimmune Cerebellar Ataxia.CEREBELLUM,18(6),1137-1142. |
MLA | Zhang Weihua,et al."Neurochondrin Antibody Serum Positivity in Three Cases of Autoimmune Cerebellar Ataxia".CEREBELLUM 18.6(2019):1137-1142. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Neurochondrin Antibo(1204KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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