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Striatal Functional Connectivity Alterations After Two-Week Antidepressant Treatment Associated to Enduring Clinical Improvement in Major Depressive Disorder
An, Jing1,2,3; Li, Le4; Wang, Li1,2; Su, Yun-Ai1,2; Wang, Ying5; Li, Ke6; Zeng, Yawei6; Kong, Qingmei1,2; Yan, Chaogan4; Si, Tianmei1,2
First AuthorAn, Jing
2019-12-06
Source PublicationFRONTIERS IN PSYCHIATRY
Correspondent Emailchaogan yan yancg@psych.ac.cn ; tianmei si si.tian-mei@163.com
ISSN1664-0640
Subtypearticle
Volume10Pages:9
Contribution Rank4
Abstract

Background: Only less than 40% of patients with Major depressive disorder (MDD) can achieve remission after several weeks of initial antidepressant treatment. Predicting whether the prescribed treatment is effective in the following course may help clinicians modify the treatment regimen in time, and reduce the staggering burden for patients and society. However, there are not yet reliable markers based on neurobiological change after a treatment regimen steadily applied, for predicting clinical treatment outcome. The striatal circuits often exhibit abnormality for MDD patients, and are implicated in antidepressant treatments. Methods: Nineteen first-episode drug-naive MDD patients (nine females, mean age was 30 years old) were recruited to undergo clinical symptom assessment and resting state fMRI scanning at baseline, after 2 and 8 weeks of treatment with duloxetine. A seed-based analysis was used to obtain functional connectivity (FC) maps of six sub-regions of the stratum, then we explored the relationship of 2-week changes of striatal FC with clinical symptom improvement after 8-week duloxetine treatment. Results: The results revealed that 2-week FC changes of the striatal cognitive and affective subdivisions with the frontoparietal regions positively correlated with 8-week symptom improvement. We also found that early FC changes between the striatal motor subdivision and the motor-related cortical regions negatively correlated with later symptom improvement. Conclusions: These findings suggest that change of the FC of the cortical-striatal circuits at the early stage of treatment is critical for later remission of MDD. Furthermore, the association between the FC change and symptom improvement may have significant implication for clinical practice to regard neural changes as reference for evaluating how antidepressant treatment works.

Keywordmajor depressive disorder antidepressant striatum prediction clinical improvement
DOI10.3389/fpsyt.2019.00884
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Beijing Municipal Science and Technology Project ; Capital Foundation of Medicine Research and Development ; National Key R&D Program of China
Funding ProjectNational Natural Science Foundation of China[81630031] ; National Natural Science Foundation of China[81671774] ; Beijing Municipal Science and Technology Project[Z171100000117016] ; Capital Foundation of Medicine Research and Development[2016-1-4111] ; National Key R&D Program of China[2017YFC1309902]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000505253000001
PublisherFRONTIERS MEDIA SA
WOS KeywordNUCLEUS-ACCUMBENS ; LARGE-SCALE ; CORTEX ; REWARD ; METAANALYSIS ; PREDICTORS ; DOPAMINE ; ORGANIZATION ; RETARDATION ; DYSFUNCTION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30576
Collection中国科学院行为科学重点实验室
Corresponding AuthorYan, Chaogan; Si, Tianmei
Affiliation1.Peking Univ Inst Mental Hlth Sixth Hosp, Clin Psychopharmacol Div, Beijing, Peoples R China
2.Peking Univ, Natl Clin Res Ctr Mental Disorders, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China
3.Beijing Huilongguan Hosp, Beijing Suicide Res & Prevent Ctr, Beijing, Peoples R China
4.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
5.984th Hosp Peoples Liberat Army China, Beijing, Peoples R China
6.306 Hosp Peoples Liberat Army, Dept Radiol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
An, Jing,Li, Le,Wang, Li,et al. Striatal Functional Connectivity Alterations After Two-Week Antidepressant Treatment Associated to Enduring Clinical Improvement in Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2019,10:9.
APA An, Jing.,Li, Le.,Wang, Li.,Su, Yun-Ai.,Wang, Ying.,...&Si, Tianmei.(2019).Striatal Functional Connectivity Alterations After Two-Week Antidepressant Treatment Associated to Enduring Clinical Improvement in Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,10,9.
MLA An, Jing,et al."Striatal Functional Connectivity Alterations After Two-Week Antidepressant Treatment Associated to Enduring Clinical Improvement in Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 10(2019):9.
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