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Interaction of oxidative stress and BDNF on executive dysfunction in patients with chronic schizophrenia
Wei, ChangWei1; Sun, Yi1; Chen, Nan2; Chen, Song2; Xiu, MeiHong2; Zhang, XiangYang3,4
First AuthorWei, ChangWei
Correspondent Emailxiumeihong97@163.com(m.xiu)
Contribution Rank3
Abstract

Executive dysfunction is increasingly recognized as one of the widely observed dimensions of cognitive impairments in the course of schizophrenia (SCZ). However, the potential molecular pathological mechanisms remain elusive. Previous studies have demonstrated that decreased brain-derived neurotrophic factor (BDNF) and oxidative damage may be associated with the psychopathology and cognitive impairment of SCZ. The present study aims to assess whether the interaction between BDNF and oxidative damage is involved in the disruption of executive function (EF) in patients with chronic SCZ. Serum BDNF and plasma oxidative stress markers were measured in 189 patients and 60 control subjects. EFs were evaluated by Wisconsin card sorting tests (WCST), Stroop word/color test (Stroop), and verbal fluency tests (VFT). The results showed that patients performed worse in the VFT, WCST and Stroop tests than healthy subjects. Moreover, patients had lower activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) and lower BDNF levels, but higher malondialdehyde (MDA) levels than healthy controls. In patients, BDNF was negatively correlated with SOD (p < 0.01). For patients, catalase (CAT) activity was negatively associated with WCST error score (p = 0.02) and BDNF was positively correlated to VFT score (p = 0.02). However, all these correlations between biomarkers and EF domains did not pass Bonferroni corrections. Finally, multiple regression analyses identified BDNF x SOD activity and BDNF x MDA as influencing factors for VFT score in patients (both p < 0.05). Our results highlight the complex interplay between OS parameters and BDNF in the pathophysiology of EF impairment in SCZ, consistent with its neurodevelopmental hypothesis.

KeywordSchizophrenia BDNF Oxidative stress Interaction Executive function
2020
Language英语
DOI10.1016/j.psyneuen.2019.104473
Source PublicationPSYCHONEUROENDOCRINOLOGY
ISSN0306-4530
Volume111Pages:7
Subtypearticle
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] ; Beijing Natural Science Foundation[7194270] ; Beijing Hospitals Authority Youth Programme[QML20190307]
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordNEUROTROPHIC FACTOR ; VAL66MET POLYMORPHISM ; COGNITIVE IMPAIRMENTS ; LIPID-PEROXIDATION ; BIOMARKERS ; METAANALYSIS ; 1ST-EPISODE ; ASSOCIATION ; PERFORMANCE ; IMPACT
WOS Research AreaEndocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
WOS SubjectEndocrinology & Metabolism ; Neurosciences ; Psychiatry
WOS IDWOS:000503085600008
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30582
Collection中国科学院心理健康重点实验室
Corresponding AuthorXiu, MeiHong
Affiliation1.Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, Beijing, Peoples R China
2.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wei, ChangWei,Sun, Yi,Chen, Nan,et al. Interaction of oxidative stress and BDNF on executive dysfunction in patients with chronic schizophrenia[J]. PSYCHONEUROENDOCRINOLOGY,2020,111:7.
APA Wei, ChangWei,Sun, Yi,Chen, Nan,Chen, Song,Xiu, MeiHong,&Zhang, XiangYang.(2020).Interaction of oxidative stress and BDNF on executive dysfunction in patients with chronic schizophrenia.PSYCHONEUROENDOCRINOLOGY,111,7.
MLA Wei, ChangWei,et al."Interaction of oxidative stress and BDNF on executive dysfunction in patients with chronic schizophrenia".PSYCHONEUROENDOCRINOLOGY 111(2020):7.
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