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Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder
Liu, Wanting1,2; Gan, Jun1; Fan, Jie1; Zheng, Hong1; Li, Sihui1; Chan, Raymond C. K.3,4; Tan, Changlian5; Zhu, Xiongzhao1,2
Corresponding AuthorTan, Changlian(tanchanglian@csu.edu.cn) ; Zhu, Xiongzhao(xiongzhaozhu@csu.edu.cn)
AbstractPoor insight in obsessive-compulsive disorder (OCD) is associated with several adverse clinical outcomes. However, the neurobiological basis of this insight deficit is not clearly understood. The present study thus aimed to investigate associations of cortical thickness, cortical surface area and subcortical volumes with insight in a sample of drug-naive adults with OCD. Forty-seven OCD patients and 42 healthy controls (HCs) underwent MRI scanning, depression and anxiety assessments. The Brown Assessment of Beliefs Scale (BABS) measured insight levels and patients were divided into two groups: poor insight (OCD-PI; n = 21), and good insight (OCD-GI; n = 26). Cortical thickness and surface area between groups were compared with whole-brain exploratory vertex-by-vertex analyses, while subcortical volumes were compared on a structure-by-structure basis. Partial correlation analyses were then performed to assess associations between regional cortical and subcortical measures and insight levels. OCD-GI and OCD-PI groups displayed partly shared, but also partly distinct brain structural alterations. Strikingly, OCD-PI showed decreased cortical thickness in the left superior frontal gyrus, left anterior cingulate cortex (ACC) and right inferior parietal gyrus, compared to both OCD-GI and HCs. Average cortical thickness extracted from these areas was further negatively correlated with BABS scores in the OCD-PI patients. Our findings suggest that poor insight in patients with OCD may have a neural substrate involving the left medial frontal and the right inferior parietal cortices.
KeywordObsessive-compulsive disorder Insight Cortical thickness Surface-based morphometry
2019
Language英语
DOI10.1016/j.nicl.2019.102037
Source PublicationNEUROIMAGE-CLINICAL
ISSN2213-1582
Volume24Pages:8
Indexed BySCI
Funding ProjectNational Key Technology Research and Development Program of the Ministry of Science and Technology of China[2012BA136B01] ; Beijing Training Project for the Leading Talents in ST[Z151100000315020] ; Strategic Priority Research Program (B) of the Chinese Academy of Science[XDB02030002]
PublisherELSEVIER SCI LTD
WOS KeywordANTERIOR CINGULATE CORTEX ; INFERIOR PARIETAL LOBULE ; POOR INSIGHT ; COGNITIVE INSIGHT ; SELF-REFLECTION ; CEREBRAL-CORTEX ; SCHIZOPHRENIA ; BRAIN ; ANOSOGNOSIA ; UNAWARENESS
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000504663800019
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30598
Collection中国科学院心理健康重点实验室
Corresponding AuthorTan, Changlian; Zhu, Xiongzhao
Affiliation1.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha 410011, Hunan, Peoples R China
2.Cent S Univ, Inst Med Psychol, Changsha, Hunan, Peoples R China
3.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Cent S Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Liu, Wanting,Gan, Jun,Fan, Jie,et al. Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder[J]. NEUROIMAGE-CLINICAL,2019,24:8.
APA Liu, Wanting.,Gan, Jun.,Fan, Jie.,Zheng, Hong.,Li, Sihui.,...&Zhu, Xiongzhao.(2019).Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder.NEUROIMAGE-CLINICAL,24,8.
MLA Liu, Wanting,et al."Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder".NEUROIMAGE-CLINICAL 24(2019):8.
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