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A modality-specific dysfunction of pain processing in schizophrenia
Zhou, Lili1,2; Bi, Yanzhi1,2; Liang, Meng3,4; Kong, Yazhuo2,5; Tu, Yiheng6,7; Zhang, Xiangyang1,2; Song, Yanying8; Du, Xia8; Tan, Shuping8; Hu, Li1,2,9
First AuthorZhou, Lili
Correspondent Emailhuli@psych.ac.cn
2019-12-23
Source PublicationHUMAN BRAIN MAPPING
ISSN1065-9471
Subtypearticle
Pages16
QuartileQ1
Contribution Rank1
Abstract

Clinical observations showed that schizophrenia (SCZ) patients reported little or no pain under various conditions that are commonly associated with intense painful sensations, leading to a higher risk of morbidity and mortality. However, this phenomenon has received little attention and its underlying neural mechanisms remain unclear. Here, we conducted two experiments combining psychophysics, electroencephalography (EEG), and functional magnetic resonance imaging (fMRI) techniques to investigate neural mechanisms of pain insensitivity in SCZ patients. Specifically, we adopted a stimulus-response paradigm with brief stimuli of different sensory modalities (i.e., nociceptive, non-nociceptive somatosensory, and auditory) to test whether pain insensitivity in SCZ patients is supra-modal or modality-specific, and used EEG and fMRI techniques to clarify its neural mechanisms. We observed that perceived intensities to nociceptive stimuli were significantly smaller in SCZ patients than healthy controls, whereas perceived intensities to non-nociceptive somatosensory and auditory stimuli were not significantly different. The behavioral results were confirmed by stimulus-evoked brain responses sampled by EEG and fMRI techniques, thus verifying the modality-specific nature of the modulation of nociceptive information processing in SCZ patients. Additionally, significant group differences were observed in the spectral power of alpha oscillations in prestimulus EEG and the seed-based functional connectivity in resting-state fMRI (seeds: the thalamus and periaqueductal gray that are key nodes in ascending and descending pain pathways respectively), suggesting a possible contribution of cortical-subcortical dysfunction to the phenomenon. Overall, our study provides insight into the neural mechanisms of pain insensitivity in SCZ and highlights a need for systematic assessments of their pain-related diseases.

Keywordelectroencephalogram functional magnetic resonance imaging pain sensitivity schizophrenia sensory processing
DOI10.1002/hbm.24906
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Informatization Special Project of Chinese Academy of Sciences ; National Key R&D Program of China ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences
Funding ProjectNational Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[81571659] ; National Natural Science Foundation of China[81971694] ; Informatization Special Project of Chinese Academy of Sciences[XXH13506-306] ; National Key R&D Program of China[2017YFC0909201] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008]
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000503963900001
PublisherWILEY
WOS KeywordBRAIN-STEM ; THALAMOCORTICAL DYSRHYTHMIA ; CENTRAL SENSITIZATION ; PHYSICAL ILLNESS ; PERCEPTION ; HYPOTHESIS ; SALIENCE ; INSENSITIVITY ; METAANALYSIS ; PREVALENCE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30604
Collection中国科学院心理健康重点实验室
Corresponding AuthorHu, Li
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Tianjin Med Univ, Sch Med Imaging, Tianjin, Peoples R China
4.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
6.Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USA
7.Harvard Med Sch, Charlestown, MA USA
8.Beijing Huilonguan Hosp, Psychiat Res Ctr, Beijing, Peoples R China
9.Guangzhou Med Univ, Affiliated Hosp 2, State Key Clin Specialty Pain Med, Dept Pain Management, Guangzhou, Guangdong, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhou, Lili,Bi, Yanzhi,Liang, Meng,et al. A modality-specific dysfunction of pain processing in schizophrenia[J]. HUMAN BRAIN MAPPING,2019:16.
APA Zhou, Lili.,Bi, Yanzhi.,Liang, Meng.,Kong, Yazhuo.,Tu, Yiheng.,...&Hu, Li.(2019).A modality-specific dysfunction of pain processing in schizophrenia.HUMAN BRAIN MAPPING,16.
MLA Zhou, Lili,et al."A modality-specific dysfunction of pain processing in schizophrenia".HUMAN BRAIN MAPPING (2019):16.
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