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An epistasis between dopaminergic and oxytocinergic systems confers risk of post-traumatic stress disorder in a traumatized Chinese cohort | |
Zhang, Kunlin1,2,3; Li, Gen1,2,3; Wang, Li1,2,3; Cao, Chengqi1,2,4; Fang, Ruojiao1,2,3; Luo, Shu5; Liu, Ping5; Zhang, Xiang Yang1,2,3 | |
第一作者 | Zhang, Kunlin |
通讯作者邮箱 | wangli1@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Post-traumatic stress disorder (PTSD) is a psychiatric syndrome that occurs after trauma exposure. Neurotransmitters such as dopamine and oxytocin have been reported to be involved in neuropathology of PTSD. Previous studies indicated that the dopamine-oxytocin interaction may contribute to behavioral disorders. Thus, exploring the epistasis (gene-gene interaction) between oxytocinergic and dopaminergic systems might be useful to reveal the genetic basis of PTSD. In this study, we analyzed two functional single nucleotide polymorphisms (SNPs), rs2268498 for oxytocinergic gene OXTR and rs1801028 for dopaminergic gene DRD2 based on putative oxytocin receptor-dopamine receptor D2 (OTR-DR2) heterocomplex in a Chinese cohort exposed to the 2008 Wenchuan earthquake (156 PTSD cases and 978 controls). Statistical analyses did not find any single variant or gene-environment interaction (SNP x earthquake-related trauma exposure) associated with provisional PTSD diagnosis or symptoms. An OXTR-DRD2 interaction (rs2268498 x rs1801028) was identified to confer risk of provisional PTSD diagnosis (OR= 9.18, 95%Cl = 3.07-27.46 and P= 7.37e-05) and further subset analysis indicated that rs2268498 genotypes controlled the association directions of rs1801028 and rs1801028 genotypes also controlled the association directions of rs2268498. Rs2268498 x rs1801028 is also associated with PTSD symptoms (P= 0.043). Our study uncovered a genetic and putative function-based contribution of dopaminergic-oxytocinergic system interaction to PTSD. |
2019-12-17 | |
语种 | 英语 |
DOI | 10.1038/s41598-019-55936-8 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 9页码:8 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31971020] ; National Natural Science Foundation of China[31470070] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4] |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | GENE POLYMORPHISMS ; SYMPTOMS ; PTSD ; BEHAVIORS ; VARIANTS ; SCHIZOPHRENIA ; ASSOCIATION ; EXPRESSION ; SUPPORT ; PCL-5 |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000503209500003 |
资助机构 | National Natural Science Foundation of China ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education ; External Cooperation Program of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30607 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Li |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Ctr Genet & BioMed Informat Res, CAS Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 4.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Guangdong, Peoples R China 5.Peoples Hosp Deyang City, Deyang 618000, Sichuan, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Kunlin,Li, Gen,Wang, Li,et al. An epistasis between dopaminergic and oxytocinergic systems confers risk of post-traumatic stress disorder in a traumatized Chinese cohort[J]. SCIENTIFIC REPORTS,2019,9:8. |
APA | Zhang, Kunlin.,Li, Gen.,Wang, Li.,Cao, Chengqi.,Fang, Ruojiao.,...&Zhang, Xiang Yang.(2019).An epistasis between dopaminergic and oxytocinergic systems confers risk of post-traumatic stress disorder in a traumatized Chinese cohort.SCIENTIFIC REPORTS,9,8. |
MLA | Zhang, Kunlin,et al."An epistasis between dopaminergic and oxytocinergic systems confers risk of post-traumatic stress disorder in a traumatized Chinese cohort".SCIENTIFIC REPORTS 9(2019):8. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
An epistasis between(1331KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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