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Impaired olfactory identification and hedonic judgment in schizophrenia patients with prominent negative symptoms
Lui, Simon S. Y.1,2; Chiu, Mindi W. Y.1; Chui, William W. H.1; Wong, Jessica O. Y.1; Man, Cappy M. Y.1; Cheung, Eric F. C.1; Chan, Raymond C. K.2,3
First AuthorLui, Simon S. Y.
Correspondent Emailraymond c. k. (chan rckchan@psych.ac.cn )
2020-03-03
Source PublicationCOGNITIVE NEUROPSYCHIATRY
ISSN1354-6805
Subtypearticle
Volume25Issue:2Pages:126-138
Contribution Rank2
Abstract

Introduction: Evidence suggests that schizophrenia patients have olfactory dysfunctions, but the relationship between olfactory identification, hedonic judgement, and negative symptomatology remains unclear. Few studies have investigated whether co-activation of pleasant and unpleasant emotions are more prevalent in schizophrenia patients. Methods: Thirty schizophrenia outpatients with prominent negative symptoms (PNS), 30 outpatients without PNS, and 30 controls completed the University of Pennsylvania Smell Identification Test, and were asked to identify the odourants and to rate their emotions. The effects of gender and medications on olfactory function were examined. Results: Schizophrenia patients exhibited olfactory identification impairments, even after accounting for gender and medication effects. Patients with PNS demonstrated larger magnitude of deficit than those without. Patients with PNS reported less pleasure to positive-valenced odourants, and less unpleasantness to negative-valenced odourants than controls. Olfactory anhedonia in patients with PNS disappeared after controlling for medication effect. Schizophrenia patients do not exhibit affective ambivalence in olfaction. Conclusions: Schizophrenia patients with PNS exhibit deficits in olfactory identification and hedonic judgement, even after controlling for gender and medication effects. Our findings support the close relationship between olfactory dysfunctions and negative symptoms. Further studies should investigate the effect of dopamine-blocking agents on the olfactory hedonic judgment in schizophrenia patients.

KeywordOlfaction anhedonia hedonic judgement schizophrenia
DOI10.1080/13546805.2019.1704709
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Programme ; National Science Fund China ; Beijing Training Project for the Leading Talents in Science and Technology ; Beijing Municipal Science & Technology Commission ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Philip KH Wong Foundation
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; National Science Fund China[81571317] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Philip KH Wong Foundation
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000503710000001
PublisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
WOS KeywordSCHIZOAFFECTIVE DISORDER ; SCALE ; DEFICIT ; PLEASURE ; ODORS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30610
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Castle Peak Hosp, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Lui, Simon S. Y.,Chiu, Mindi W. Y.,Chui, William W. H.,et al. Impaired olfactory identification and hedonic judgment in schizophrenia patients with prominent negative symptoms[J]. COGNITIVE NEUROPSYCHIATRY,2020,25(2):126-138.
APA Lui, Simon S. Y..,Chiu, Mindi W. Y..,Chui, William W. H..,Wong, Jessica O. Y..,Man, Cappy M. Y..,...&Chan, Raymond C. K..(2020).Impaired olfactory identification and hedonic judgment in schizophrenia patients with prominent negative symptoms.COGNITIVE NEUROPSYCHIATRY,25(2),126-138.
MLA Lui, Simon S. Y.,et al."Impaired olfactory identification and hedonic judgment in schizophrenia patients with prominent negative symptoms".COGNITIVE NEUROPSYCHIATRY 25.2(2020):126-138.
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