PSYCH OpenIR  > 中国科学院心理健康重点实验室
Correlation between hypothalamic-pituitary-adrenal axis gene polymorphisms and posttraumatic stress disorder symptoms
Zhang, Kunlin1,2,3; Wang, Li1,2,3; Li, Gen1,2,3; Cao, Chengqi1,2,4; Fang, Ruojiao1,2,3; Liu, Ping5; Luo, Shu5; Zhang, Xiangyang1,2,3
First AuthorZhang, Kunlin
Correspondent Emailwangli1@psych.ac.cn(l.wang)
Contribution Rank1
Abstract

Background: The hypothalamic-pituitary-adrenal (FIFA) axis is the main neuroendocrine system that controls stress responses, including fear learning. To further understand the correlation between the HPA axis and stress and fear-related symptoms in humans, the current study investigated the relationship between HPA axis gene polymorphisms and a stress- and fear-related disorder, posttraumatic stress disorder (PTSD). This is the first study that systematically investigates the correlations between HPA axis genes and distinct PTSD symptom clusters. Methods: Participants included 1132 Chinese earthquake survivors (772 women and 360 men). PTSD symptoms were measured by the PTSD Checklist for DSM-5 (PCL-5), and the severity (total symptoms) and symptom clusters were calculated according to the hybrid seven-factor model of DSM-5 PTSD. We genotyped eight single nucleotide polymorphisms (SNPs) of three HPA axis genes, including FKBP5, CRHR1 and CRHR2. Results: The main effects of the CRHR2 SNP rs2267715 were associated with PTSD severity (P = 0.0035) and all PTSD symptom clusters except dysphoric arousal (P ranging from 0.0011 to 0.048). In women, a gene environment interaction (G x E) effect of FKBP5 (rs3800373 x trauma exposure) was correlated with PTSD severity (P = 0.038), externalizing behaviors, anxious arousal and dysphoric arousal symptoms (P ranging from 0.014 to 0.028); the G x E effect of CRHR1 (rs4458044 x trauma exposure) was associated with anxious arousal symptoms (P = 0.016). In men, a gene gene interaction (G x G) effect of FKBP5 CRHR1 (rs9470080 x rs4458044) was associated with PTSD severity (P = 0.0091), intrusion, negative affect, externalizing behaviors and anxious arousal (P ranging 0.012-0.049). Conclusion: Our results systematically revealed that the main effects and G x E and G x G effects of some genetic polymorphisms of HPA axis genes are involved in the severity and distinct symptom clusters of PTSD.

KeywordHypothalamic-pituitary-adrenal (HPA) axis Gene Stress response Symptoms Posttraumatic stress disorder (PTSD)
2020
Language英语
DOI10.1016/j.yhbeh.2019.104604
Source PublicationHORMONES AND BEHAVIOR
ISSN0018-506X
Volume117Pages:8
Subtypearticle
Indexed BySCI
Funding ProjectExternal. Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; National Natural Science Foundation of China[31971020] ; National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31470070] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4]
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordDSM-5 PTSD SYMPTOMS ; EARLY-LIFE STRESS ; HORMONE-RECEPTOR GENE ; FKBP5 POLYMORPHISMS ; GLUCOCORTICOID-RECEPTOR ; CHILDHOOD ABUSE ; NATIONAL-HEALTH ; ASSOCIATION ; RISK ; FEAR
WOS Research AreaBehavioral Sciences ; Endocrinology & Metabolism
WOS SubjectBehavioral Sciences ; Endocrinology & Metabolism
WOS IDWOS:000509438000014
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30622
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Li
Affiliation1.Inst Psychol, Lab Traumat Stress Studies, Beijing 100101, Peoples R China
2.Inst Psychol, Ctr Genet & BioMed Informat Res, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
4.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Peoples R China
5.Peoples Hosp Deyang City, Deyang 618000, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Kunlin,Wang, Li,Li, Gen,et al. Correlation between hypothalamic-pituitary-adrenal axis gene polymorphisms and posttraumatic stress disorder symptoms[J]. HORMONES AND BEHAVIOR,2020,117:8.
APA Zhang, Kunlin.,Wang, Li.,Li, Gen.,Cao, Chengqi.,Fang, Ruojiao.,...&Zhang, Xiangyang.(2020).Correlation between hypothalamic-pituitary-adrenal axis gene polymorphisms and posttraumatic stress disorder symptoms.HORMONES AND BEHAVIOR,117,8.
MLA Zhang, Kunlin,et al."Correlation between hypothalamic-pituitary-adrenal axis gene polymorphisms and posttraumatic stress disorder symptoms".HORMONES AND BEHAVIOR 117(2020):8.
Files in This Item:
File Name/Size DocType Version Access License
Correlation between (1099KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Kunlin]'s Articles
[Wang, Li]'s Articles
[Li, Gen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Kunlin]'s Articles
[Wang, Li]'s Articles
[Li, Gen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Kunlin]'s Articles
[Wang, Li]'s Articles
[Li, Gen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.