Institutional Repository of Key Laboratory of Mental Health, CAS
Prevalence and clinical correlates of psychotic depression in first-episode and drug-naive outpatients with major depressive disorder in a Chinese Han population | |
Zhou, Yongjie1,2; Li, Zezhi3; Wang, Yijun1,2; Huang, Huiteng1,2; Chen, Wencai1,2; Dong, Ling1,2; Wu, Jiang4; Chen, Jing1,2,4; Miao, Ying1,2; Qi, Ling4,5; Zhang, Shufang1,2,4; Lang, Xiaoe6; Zhang, Xiangyang7,8![]() | |
通讯作者邮箱 | drpsychiatryli@sina.com (z. li) ; zhangxy@psych.ac.cn (x. zhang) |
心理所单位排序 | 7 |
摘要 | Background: Few systemic studies of psychotic depression (PD) have been conducted in first-episode and drug-naive (FEDN) patients. This study was to examine the prevalence of PD and its clinical correlates in a large sample of FEDN outpatients with major depressive disorder (MDD) in a Chinese Han population, which to our best knowledge has not been studied. Methods: In this cross-sectional study, a total of 1718 FEDN MDD outpatients were recruited. All patients were rated on the positive symptom subscale of the Positive and Negative Syndrome Scale (PANSS) for psychotic symptoms, the 17-item Hamilton Depression Rating Scale (HAMD-17) for depression and Hamilton Anxiety Rating Scale (HAMA) for anxiety. Results: The prevalence of PD was 10.0% (171/1718) in MDD patients. Compared to the non-PD patients, PD patients had significantly older age, lower educational levels, higher anxiety symptom score and were more likely to attempt suicide. Further logistic regression analysis indicated that PD was associated with older age, suicide attempt and comorbid anxiety (all p < 0.05). Multiple regression analyses showed that both HAMD and HAMA total scores were significantly associated with PANSS positive symptom subscale score. Limitations: Our cross-sectional study design does not show a direct causal relationship between psychiatric symptoms and related factors in patients with MDD. Conclusions: Our results suggest a high prevalence of PD in MDD patients in the acute early stage in a Chinese Han population, which is associated with demographic variables and clinical symptoms. |
2020-02-15 | |
语种 | 英语 |
DOI | 10.1016/j.jad.2019.10.051 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS
![]() |
ISSN | 0165-0327 |
卷号 | 263页码:500-506 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | research project of Wuhan health and planning Business Committee[WX15C06] ; research project of Wuhan health and planning Business Committee[WG12A0] ; research project of Wuhan health and planning Business Committee[WG16C08] |
出版者 | ELSEVIER |
WOS关键词 | SUICIDE ; SYMPTOMS ; RISK ; ASSOCIATION ; BIPOLAR ; SCHIZOPHRENIA ; SEVERITY ; FEATURES ; CLASSIFICATION ; ADOLESCENTS |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000508874400064 |
资助机构 | research project of Wuhan health and planning Business Committee |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30640 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Li, Zezhi; Zhang, Xiangyang |
作者单位 | 1.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China 2.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Tongji Med Coll, Wuhan, Peoples R China 3.Shanghai Jiao Tong Univ, Ren Ji Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China 4.Wuhan Youfu Hosp, Wuhan, Peoples R China 5.Wuhan Polytech Univ, Sch Hlth Sci & Nursing, Wuhan 430023, Peoples R China 6.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China 7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 8.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Zhou, Yongjie,Li, Zezhi,Wang, Yijun,et al. Prevalence and clinical correlates of psychotic depression in first-episode and drug-naive outpatients with major depressive disorder in a Chinese Han population[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,263:500-506. |
APA | Zhou, Yongjie.,Li, Zezhi.,Wang, Yijun.,Huang, Huiteng.,Chen, Wencai.,...&Zhang, Xiangyang.(2020).Prevalence and clinical correlates of psychotic depression in first-episode and drug-naive outpatients with major depressive disorder in a Chinese Han population.JOURNAL OF AFFECTIVE DISORDERS,263,500-506. |
MLA | Zhou, Yongjie,et al."Prevalence and clinical correlates of psychotic depression in first-episode and drug-naive outpatients with major depressive disorder in a Chinese Han population".JOURNAL OF AFFECTIVE DISORDERS 263(2020):500-506. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Prevalence and clini(372KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论