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Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice
Wang, Qiong1; Liu, Yingjuan2; Zhang, Jianxu3; Wang, Weiwen4,5
First AuthorWang, Qiong
Correspondent Emailjianxu zhang zhangjx@ioz.ac.cn ; weiwen wang wangww@psych.ac.cn
Contribution Rank3
Abstract

Stress inoculation has been proved to induce active coping behaviors to subsequent stress. However, the specific neural mechanisms underlying this effect remain unclear. In this study, a chronic and mild predator odor exposure model was established to investigate the effect of predator odor stress inoculation on behaviors in novel predator odor exposure, open field test and forced swimming test (FST), and on the expression of CRF receptors in locus coeruleus (LC) and dorsal raphe nuclei (DRN). The results showed that predator odor stress inoculation increased the active coping of mice under the severe stress environment without changing the stress response to a new predator odor. Meanwhile, in LC, the CRFR1 expression was increased by predator odor stress inoculation. These results suggested that predator odor stress inoculation can be used as an effective training method to improve active response to later severe stress and the function of CRFR1 in LC might be a potential underlying biological mechanism.

Keywordstress inoculation predator odor exposure active coping corticotropin-releasing factor receptors locus coeruleus dorsal raphe nuclei
2020-01-10
Language英语
DOI10.3389/fpsyg.2019.03028
Source PublicationFRONTIERS IN PSYCHOLOGY
ISSN1664-1078
Volume10Pages:8
Subtypearticle
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31771217] ; National Natural Science Foundation of China[81471122] ; National Natural Science Foundation of China[31900786] ; MOE (Ministry of Education in China) Project of Humanities and Social Sciences[18YJC190022] ; Henan Society Project Planning[2018BTY019] ; University Key Scientific Research Project Plan of Henan Province[19A190005] ; Henan Provincial Department of Education Project of Humanities and Social Sciences[2019-ZZJH-528] ; Henan Education Science 13th Five-Year Plan planning issues[2018-JKGHYB-0008]
PublisherFRONTIERS MEDIA SA
WOS KeywordSTRESS INOCULATION ; EXPOSURE ; NUCLEUS ; ANXIETY ; CONSEQUENCES ; MODEL ; RATS ; CRF
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000509278400001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30652
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Jianxu; Wang, Weiwen
Affiliation1.Zhengzhou Univ, Sch Educ, Zhengzhou, Peoples R China
2.Nanyang Normal Univ, Sch Life Sci & Technol, Nanyang, Peoples R China
3.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Qiong,Liu, Yingjuan,Zhang, Jianxu,et al. Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice[J]. FRONTIERS IN PSYCHOLOGY,2020,10:8.
APA Wang, Qiong,Liu, Yingjuan,Zhang, Jianxu,&Wang, Weiwen.(2020).Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice.FRONTIERS IN PSYCHOLOGY,10,8.
MLA Wang, Qiong,et al."Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice".FRONTIERS IN PSYCHOLOGY 10(2020):8.
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