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Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors | |
Wang, Dongmei1,2; Zhang, Jianjun1,2; Bai, Yunjing1,2; Zheng, Xigeng1,2; Alizamini, Mirmohammadali M.1,2; Shang, Wen1,2; Yang, Qingxiong3; Li, Ming4; Li, Yonghui1,2; Sui, Nan1,2 | |
第一作者 | Wang, Dongmei |
通讯作者邮箱 | liyonghui@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Background: Identifying neural substrates that are differentially affected by drugs of abuse and natural rewards is key to finding a target for an efficacious treatment for substance abuse. Melanin-concentrating hormone is a polypeptide with an inhibitory effect on the mesolimbic dopamine system. Here we test the hypothesis that melanin-concentrating hormone in the lateral hypothalamus and nucleus accumbens shell is differentially involved in the regulation of morphine and food-rewarded behaviors. Methods: Male Sprague-Dawley rats were trained with morphine (5.0 mg/kg, subcutaneously) or food pellets (standard chow, 10-14 g) to induce a conditioned place preference, immediately followed by extinction training. Melanin-concentrating hormone (1.0 mu g/side) or saline was infused into the nucleus accumbens shell or lateral hypothalamus before the reinstatement primed by morphine or food, and locomotor activity was simultaneously monitored. As the comparison, melanin-concentrating hormone was also microinjected into the nucleus accumbens shell or lateral hypothalamus before the expression of food or morphine-induced conditioned place preference. Results: Microinfusion of melanin-concentrating hormone into the nucleus accumbens shell (but not into the lateral hypothalamus) prevented the reinstatement of morphine conditioned place preference but had no effect on the reinstatement of food conditioned place preference. In contrast, microinfusion of melanin-concentrating hormone into the lateral hypothalamus (but not in the nucleus accumbens shell) inhibited the reinstatement of food conditioned place preference but had no effect on the reinstatement of morphine conditioned place preference. Conclusions: These results suggest a clear double dissociation of melanin-concentrating hormone in morphine/food rewarding behaviors and melanin-concentrating hormone in the nucleus accumbens shell. Melanin-concentrating hormone could be a potential target for therapeutic intervention for morphine abuse without affecting natural rewards. |
关键词 | Melanin-concentrating hormone morphine food nucleus accumbens shell lateral hypothalamus |
2020-01-07 | |
语种 | 英语 |
DOI | 10.1177/0269881119895521 |
发表期刊 | JOURNAL OF PSYCHOPHARMACOLOGY |
ISSN | 0269-8811 |
页码 | 12 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Key Research and Development Program of China[2017YFC1310405] ; National Natural Science Foundation of China[U1736124] ; National Natural Science Foundation of China[31371035] ; CAS Key Lab of Mental Health |
出版者 | SAGE PUBLICATIONS LTD |
WOS关键词 | CONDITIONED PLACE PREFERENCE ; COCAINE-INDUCED REINSTATEMENT ; GLUTAMATE TRANSMISSION ; ELECTRICAL-STIMULATION ; SYNAPTIC PLASTICITY ; DOPAMINE RELEASE ; VENTRAL STRIATUM ; NATURAL REWARDS ; DRUG-SEEKING ; ALPHA-MSH |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
WOS类目 | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
WOS记录号 | WOS:000507000000001 |
资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Key Lab of Mental Health |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30664 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Li, Yonghui |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Guizhou Normal Univ, Sch Karst Sci, State Engn Technol Inst Karst Desertificat Contro, Guiyang, Peoples R China 4.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wang, Dongmei,Zhang, Jianjun,Bai, Yunjing,et al. Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2020:12. |
APA | Wang, Dongmei.,Zhang, Jianjun.,Bai, Yunjing.,Zheng, Xigeng.,Alizamini, Mirmohammadali M..,...&Sui, Nan.(2020).Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors.JOURNAL OF PSYCHOPHARMACOLOGY,12. |
MLA | Wang, Dongmei,et al."Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors".JOURNAL OF PSYCHOPHARMACOLOGY (2020):12. |
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