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Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors
Wang, Dongmei1,2; Zhang, Jianjun1,2; Bai, Yunjing1,2; Zheng, Xigeng1,2; Alizamini, Mirmohammadali M.1,2; Shang, Wen1,2; Yang, Qingxiong3; Li, Ming4; Li, Yonghui1,2; Sui, Nan1,2
First AuthorWang, Dongmei
Correspondent Emailliyonghui@psych.ac.cn
2020-01-07
Source PublicationJOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
Subtypearticle
Pages12
Contribution Rank1
Abstract

Background: Identifying neural substrates that are differentially affected by drugs of abuse and natural rewards is key to finding a target for an efficacious treatment for substance abuse. Melanin-concentrating hormone is a polypeptide with an inhibitory effect on the mesolimbic dopamine system. Here we test the hypothesis that melanin-concentrating hormone in the lateral hypothalamus and nucleus accumbens shell is differentially involved in the regulation of morphine and food-rewarded behaviors. Methods: Male Sprague-Dawley rats were trained with morphine (5.0 mg/kg, subcutaneously) or food pellets (standard chow, 10-14 g) to induce a conditioned place preference, immediately followed by extinction training. Melanin-concentrating hormone (1.0 mu g/side) or saline was infused into the nucleus accumbens shell or lateral hypothalamus before the reinstatement primed by morphine or food, and locomotor activity was simultaneously monitored. As the comparison, melanin-concentrating hormone was also microinjected into the nucleus accumbens shell or lateral hypothalamus before the expression of food or morphine-induced conditioned place preference. Results: Microinfusion of melanin-concentrating hormone into the nucleus accumbens shell (but not into the lateral hypothalamus) prevented the reinstatement of morphine conditioned place preference but had no effect on the reinstatement of food conditioned place preference. In contrast, microinfusion of melanin-concentrating hormone into the lateral hypothalamus (but not in the nucleus accumbens shell) inhibited the reinstatement of food conditioned place preference but had no effect on the reinstatement of morphine conditioned place preference. Conclusions: These results suggest a clear double dissociation of melanin-concentrating hormone in morphine/food rewarding behaviors and melanin-concentrating hormone in the nucleus accumbens shell. Melanin-concentrating hormone could be a potential target for therapeutic intervention for morphine abuse without affecting natural rewards.

KeywordMelanin-concentrating hormone morphine food nucleus accumbens shell lateral hypothalamus
DOI10.1177/0269881119895521
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Key Lab of Mental Health
Funding ProjectNational Key Research and Development Program of China[2017YFC1310405] ; National Natural Science Foundation of China[U1736124] ; National Natural Science Foundation of China[31371035] ; CAS Key Lab of Mental Health
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000507000000001
PublisherSAGE PUBLICATIONS LTD
WOS KeywordCONDITIONED PLACE PREFERENCE ; COCAINE-INDUCED REINSTATEMENT ; GLUTAMATE TRANSMISSION ; ELECTRICAL-STIMULATION ; SYNAPTIC PLASTICITY ; DOPAMINE RELEASE ; VENTRAL STRIATUM ; NATURAL REWARDS ; DRUG-SEEKING ; ALPHA-MSH
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30664
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Yonghui
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Guizhou Normal Univ, Sch Karst Sci, State Engn Technol Inst Karst Desertificat Contro, Guiyang, Peoples R China
4.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Dongmei,Zhang, Jianjun,Bai, Yunjing,et al. Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2020:12.
APA Wang, Dongmei.,Zhang, Jianjun.,Bai, Yunjing.,Zheng, Xigeng.,Alizamini, Mirmohammadali M..,...&Sui, Nan.(2020).Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors.JOURNAL OF PSYCHOPHARMACOLOGY,12.
MLA Wang, Dongmei,et al."Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors".JOURNAL OF PSYCHOPHARMACOLOGY (2020):12.
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