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Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression
Zhou, Hui-Xia1,2,3; Chen, Xiao1,2,3; Shen, Yang-Qian1; Li, Le1,2,3; Chen, Ning-Xuan1,2,3; Zhu, Zhi-Chen1,2,3; Castellanos, Francisco Xavier5,6; Yan, Chao-Gan1,2,3,4,5
First AuthorZhou, Hui-Xia
Correspondent Emailyancg@psych.ac.cn
2020-02-01
Source PublicationNEUROIMAGE
ISSN1053-8119
Subtypearticle
Volume206Pages:9
QuartileQ1
Contribution Rank1
Abstract

Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination.

KeywordRumination Depression Default mode network Core regions Dorsal medial prefrontal cortex subsystem
DOI10.1016/j.neuroimage.2019.116287
Indexed BySCI
Language英语
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences
Funding ProjectNational Key R&D Program of China[2017YFC1309902] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505]
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000507987000038
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordSELF-FOCUS ; AUTOBIOGRAPHICAL MEMORY ; DISORDER ; FUTURE ; JUDGMENTS ; SYMPTOMS ; SEARCH ; MATTER
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30676
Collection中国科学院行为科学重点实验室
Corresponding AuthorYan, Chao-Gan
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Int Big Data Ctr Depress Res, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
5.NYU Langone, Hassenfeld Childrens Hosp, Dept Child & Adolescent Psychiat, New York, NY USA
6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
Recommended Citation
GB/T 7714
Zhou, Hui-Xia,Chen, Xiao,Shen, Yang-Qian,et al. Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression[J]. NEUROIMAGE,2020,206:9.
APA Zhou, Hui-Xia.,Chen, Xiao.,Shen, Yang-Qian.,Li, Le.,Chen, Ning-Xuan.,...&Yan, Chao-Gan.(2020).Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression.NEUROIMAGE,206,9.
MLA Zhou, Hui-Xia,et al."Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression".NEUROIMAGE 206(2020):9.
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