Structural and functional abnormality of the putamen in children with developmental dyslexia

doi:10.1016/j.neuropsychologia.2018.07.014

PSYCH OpenIR > 认知与发展心理学研究室

	Structural and functional abnormality of the putamen in children with developmental dyslexia
	Wang, Zhao 1,2,3,4; Yan, Xin 4; Liu, Yanni 5; Spray, Gregory J.4; Deng, Yuan6 ; Cao, Fan 1,2,4,7
通讯作者	Cao, Fan(caofan3@mail.sysu.edu.cn)
摘要	There is currently debate with regards to the role of phonological deficit in Chinese reading difficulty, even though some researchers have suggested that the deficit of phonological processing is also a signature of developmental dyslexia in Chinese, as has been found in alphabetic languages. In this study, we examined the brain mechanisms of phonological deficit in Chinese children with developmental dyslexia (DD) during an auditory rhyming judgment task. First, we examined structural differences in Chinese dyslexia by comparing gray and white matter volume in Chinese children with DD, age-matched controls (AC), and reading-matched controls (RC). Next, we examined whether the regions with an abnormal volume in DD showed deficient functional connectivity with the rest of the brain during a phonological task (i.e. auditory rhyming judgment). We found that both AC and RC had greater gray matter volume (GMV) at the left putamen and right dorsal lateral frontal cortex than DD, suggesting possible neural signatures of developmental dyslexia. Functional connectivity analysis revealed that the left putamen was more connected with the right inferior occipital gyrus (IOG) in AC and RC than in DD, suggesting that automatic orthographic involvement during spoken language processing is more salient in controls, while the left putamen was more connected with the left transverse temporal gyrus (TTG) and left insula in DD than in AC and RC, suggesting the phonological articulation-auditory feedback loop is more involved in DD. These findings suggest that the reduced left putamen might contribute to phonological deficits experienced in DD, since it showed deficient connectivity with the rest of the brain during phonological processing.
关键词	Dyslexia fMRI Phonological deficit Putamen VBM PPI
	2019-07-01
语种	英语
DOI	10.1016/j.neuropsychologia.2018.07.014
发表期刊	NEUROPSYCHOLOGIA
ISSN	0028-3932
卷号	130 页码:26-37
收录类别	SCI
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	HUMAN AUDITORY-CORTEX ; WORKING-MEMORY DEFICITS ; VOXEL-BASED MORPHOMETRY ; PHONOLOGICAL AWARENESS ; LANGUAGE IMPAIRMENT ; READING DEVELOPMENT ; FMRI CONNECTIVITY ; WORD RECOGNITION ; BASAL GANGLIA ; EARLY CHINESE
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS类目	Behavioral Sciences ; Neurosciences ; Psychology, Experimental
WOS记录号	WOS:000493912900004
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/30725
专题	认知与发展心理学研究室
通讯作者	Cao, Fan
作者单位	1.Sun Yat Sen Univ, Guangdong Prov Key Lab Social Cognit Neurosci & M, Guangzhou, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China 3.Beijing Normal Univ, Beijing, Peoples R China 4.Michigan State Univ, Dept Commun Sci & Disorders, E Lansing, MI 48824 USA 5.Univ Michigan, Ann Arbor, MI 48109 USA 6.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 7.Chinese Univ Hong Kong, Sch Humanities & Social Sci, Shenzhen, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhao,Yan, Xin,Liu, Yanni,et al. Structural and functional abnormality of the putamen in children with developmental dyslexia[J]. NEUROPSYCHOLOGIA,2019,130:26-37.
APA	Wang, Zhao,Yan, Xin,Liu, Yanni,Spray, Gregory J.,Deng, Yuan,&Cao, Fan.(2019).Structural and functional abnormality of the putamen in children with developmental dyslexia.NEUROPSYCHOLOGIA,130,26-37.
MLA	Wang, Zhao,et al."Structural and functional abnormality of the putamen in children with developmental dyslexia".NEUROPSYCHOLOGIA 130(2019):26-37.