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Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis
Yang Zhuo-ya1,2; Wang Shuang-kun3; Li Ying1,2,4; Wang Yi1; Wang Yong-ming1,2,5,6; Zhou Han-yu1,2; Cai Xin-lu1,2,5,6; Eric, Cheung F. C.7; Shum, David H. K.1,8; Ongur, Dost9; Raymond, Chan C. K.1,2
First AuthorYang Zhuo-ya
Correspondent Emailrckchan@psych.ac.cn (r.c.k. chan)
Contribution Rank1
Abstract

Prospection, which has a close relationship with motivation and goal-directed behavior, could be a potential target for alleviating negative symptoms. The present study aimed to examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients. Thirty-seven patients with schizophrenia and 28 healthy controls were recruited and all of them completed a prospection task. Working memory was assessed with the Letter Number Span test. In addition, all participants underwent a structural MRI scan. Voxel-based morphometry (VBM) analysis was used to measure grey matter (GM) volume. We found that in schizophrenia patients, GM loss in the right lateral prefrontal cortex (PFC) and the right ventral medial PFC was correlated with decreased internal details in the prospection task. Moreover, GM volume of the right lateral PFC was found to mediate the relationship between working memory and internal details in these patients. In conclusion, GM loss in the PFC is associated with prospection impairments in schizophrenia patients. Working memory deficits may partially account for prospection impairments in schizophrenia patients.

KeywordProspection Working memory Schizophrenia Voxel-based morphometry
2019-11-30
Language英语
DOI10.1016/j.pscychresns.2019.110987
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
Volume293Pages:6
Subtypearticle
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; National Science Fund China[81571317] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020]
PublisherELSEVIER IRELAND LTD
WOS KeywordEPISODIC FUTURE THINKING ; MENTAL TIME-TRAVEL ; WORKING-MEMORY ; SIMULATION ; DEFICITS ; EVENTS ; METAANALYSIS ; COMPONENT
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000492704000004
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30741
Collection中国科学院心理健康重点实验室
Corresponding AuthorRaymond, Chan C. K.
Affiliation1.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Capital Med Univ, Beijing Chao Yang Hosp, Dept Radiol, Beijing, Peoples R China
4.Haidian Dist Mental Hlth Prevent Treatment Hosp, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100190, Peoples R China
6.Sinodanish Ctr Educ & Res, Beijing 100190, Peoples R China
7.Castle Peak Hosp, Hong Kong, Peoples R China
8.Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China
9.Harvard Med Sch, McLean Hosp, Dept Psychiat, 115 Mill St, Belmont, MA USA
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Yang Zhuo-ya,Wang Shuang-kun,Li Ying,et al. Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2019,293:6.
APA Yang Zhuo-ya.,Wang Shuang-kun.,Li Ying.,Wang Yi.,Wang Yong-ming.,...&Raymond, Chan C. K..(2019).Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis.PSYCHIATRY RESEARCH-NEUROIMAGING,293,6.
MLA Yang Zhuo-ya,et al."Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis".PSYCHIATRY RESEARCH-NEUROIMAGING 293(2019):6.
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