Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention

doi:10.16476/j.pibb.2019.0079

	Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention
	Liu Wang 1,2; Chen Qiao 1,2; Li Yong-Hui1,2
通讯作者	Li Yong-Hui(liyonghui@pscy.ac.cn)
摘要	Relapse behavior after long-term abstinence is the key problem of addiction treatment. A major factor to induce relapse is the persistence of maladaptive drug-associated memories. Persistent changes in structure and function of prefrontal cortex-mesolimbic dopamine system caused by chronic drug abusing, lead to the formation of pathological drug-associated memories. This article reviews addiction with a focus on how it can be conceptualised as a disorder of maladaptive memory, considering the neural basis of drug-associated memories during the initial phase, the habituation phase and the maintenance phase of addictive behavior. The present review summarizes the clinical intervention methods of drug-associated memories in recent years including extinction training, extinction in multiple contexts to facilitate extinction and reconsolidation intervention to disrupt drug-associated memories directly, and the application of virtual reality technology and neuromodulation methods in addiction intervention. The intervention methods combined memory reconsolidation with virtual reality technology or neuromodulation methods are prospected to target drug-associated memories, providing new methods and new ideas to treat addiction in future clinical researches.
关键词	drug-associated memories neurobiological mechanism extinction training memory reconsolidation virtual reality neuromodulation
	2019-10-01
语种	英语
DOI	10.16476/j.pibb.2019.0079
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
卷号	46 期号:10 页码:941-951
收录类别	SCI
资助项目	National Key Research and Development Program of China[2017YFC1310405] ; National Key Research and Development Program of China[2016YFC0800907] ; National Natural Science Foundation of China[U1736124] ; CAS Key Lab of Mental Health
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS关键词	DIRECT-CURRENT STIMULATION ; DEEP BRAIN-STIMULATION ; CUE-EXPOSURE THERAPY ; POST-RETRIEVAL EXTINCTION ; MEDIAL PREFRONTAL CORTEX ; COCAINE-SEEKING ; NUCLEUS-ACCUMBENS ; INDUCED REINSTATEMENT ; BASOLATERAL AMYGDALA ; VIRTUAL-REALITY
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000492109100001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Key Lab of Mental Health
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/30757
专题	中国科学院心理健康重点实验室
通讯作者	Li Yong-Hui
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Liu Wang,Chen Qiao,Li Yong-Hui. Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2019,46(10):941-951.
APA	Liu Wang,Chen Qiao,&Li Yong-Hui.(2019).Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,46(10),941-951.
MLA	Liu Wang,et al."Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 46.10(2019):941-951.