Institutional Repository of Key Laboratory of Mental Health, CAS
Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation | |
Ma, Longyu1,2; Yue, Lupeng3,4; Zhang, Yuqi1,2; Wang, Yue1,2; Han, Bingxuan1,2; Cui, Shuang1,2; Liu, Feng-Yu1,2; Wan, You1,2,5,6; Yi, Ming1,2,5 | |
第一作者 | Ma, Longyu |
通讯作者邮箱 | ywan@hsc.pku.edu.cn (y.w.) ; mingyi@hsc.pku.edu.cn (m.y.) |
心理所单位排序 | 3 |
摘要 | Pain involves an intrinsically dynamic connectome characterized by fluctuating spontaneous brain activity and continuous neuroplastic changes of relevant circuits. Activity in the hippocampus-medial prefrontal cortex (mPFC) pathway has been suggested to correlate with spontaneous pain and pain chronicity, but causal evidence is lacking. Here we combine longitudinal in vivo electrophysiological recording with behavioral testing and show that persistent spontaneous pain disrupts ventral hippocampal CA1-infralimbic cortex (vCA1-IL) connectivity and hippocampal modulation of IL neuronal activity in rats with peripheral inflammation. Chemo- and optogenetic rescue of vCA1-IL dysfunction relieves spontaneous pain. Circuit-specific overexpression of brain-derived neurotrophic factor (BDNF) in vCA1-IL reverses electrophysiological changes, relieves spontaneous pain, and accelerates overall recovery from inflammatory pain. Our work identifies a neural pathway that specifically correlates with spontaneous pain and supports the significance of using a circuit dynamics-based strategy for more comprehensive understanding of circuitry mechanisms underlying chronic pain. |
2019-11-05 | |
语种 | 英语 |
DOI | 10.1016/j.celrep.2019.10.002 |
发表期刊 | CELL REPORTS |
ISSN | 2211-1247 |
卷号 | 29期号:6页码:1579-+ |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Basic Research Program of the Ministry of Science and Technology of China[2014CB548200] ; National Basic Research Program of the Ministry of Science and Technology of China[2015CB554503] ; National Natural Science Foundation of China[91732107] ; National Natural Science Foundation of China[81571067] ; National Natural Science Foundation of China[81521063] ; National Natural Science Foundation of China[31872774] ; National Natural Science Foundation of China[81974166] ; Beijing Natural Science Foundation[5182013] ; Key Project of the Chinese Ministry of Education[109003] ; 111'' Project of the Ministry of Education of China[B07001] |
出版者 | CELL PRESS |
WOS关键词 | MEDIAL PREFRONTAL CORTEX ; FUNCTIONAL CONNECTIVITY ; NEUROPATHIC PAIN ; ADULT NEUROGENESIS ; BACK-PAIN ; BRAIN ; NEURONS ; STIMULATION ; TRANSITION ; PATHWAYS |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000495045400016 |
资助机构 | National Basic Research Program of the Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Key Project of the Chinese Ministry of Education ; 111'' Project of the Ministry of Education of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30789 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wan, You; Yi, Ming |
作者单位 | 1.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100083, Peoples R China 2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China 5.Peking Univ, Key Lab Neurosci, Natl Hlth Commiss, Minist Educ, Beijing 100083, Peoples R China 6.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China |
推荐引用方式 GB/T 7714 | Ma, Longyu,Yue, Lupeng,Zhang, Yuqi,et al. Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation[J]. CELL REPORTS,2019,29(6):1579-+. |
APA | Ma, Longyu.,Yue, Lupeng.,Zhang, Yuqi.,Wang, Yue.,Han, Bingxuan.,...&Yi, Ming.(2019).Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation.CELL REPORTS,29(6),1579-+. |
MLA | Ma, Longyu,et al."Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation".CELL REPORTS 29.6(2019):1579-+. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Spontaneous Pain Dis(6260KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论