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Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation
Ma, Longyu1,2; Yue, Lupeng3,4; Zhang, Yuqi1,2; Wang, Yue1,2; Han, Bingxuan1,2; Cui, Shuang1,2; Liu, Feng-Yu1,2; Wan, You1,2,5,6; Yi, Ming1,2,5
First AuthorMa, Longyu
Correspondent Emailywan@hsc.pku.edu.cn (y.w.) ; mingyi@hsc.pku.edu.cn (m.y.)
2019-11-05
Source PublicationCELL REPORTS
ISSN2211-1247
Subtypearticle
Volume29Issue:6Pages:1579-+
Contribution Rank3
Abstract

Pain involves an intrinsically dynamic connectome characterized by fluctuating spontaneous brain activity and continuous neuroplastic changes of relevant circuits. Activity in the hippocampus-medial prefrontal cortex (mPFC) pathway has been suggested to correlate with spontaneous pain and pain chronicity, but causal evidence is lacking. Here we combine longitudinal in vivo electrophysiological recording with behavioral testing and show that persistent spontaneous pain disrupts ventral hippocampal CA1-infralimbic cortex (vCA1-IL) connectivity and hippocampal modulation of IL neuronal activity in rats with peripheral inflammation. Chemo- and optogenetic rescue of vCA1-IL dysfunction relieves spontaneous pain. Circuit-specific overexpression of brain-derived neurotrophic factor (BDNF) in vCA1-IL reverses electrophysiological changes, relieves spontaneous pain, and accelerates overall recovery from inflammatory pain. Our work identifies a neural pathway that specifically correlates with spontaneous pain and supports the significance of using a circuit dynamics-based strategy for more comprehensive understanding of circuitry mechanisms underlying chronic pain.

DOI10.1016/j.celrep.2019.10.002
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of the Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Key Project of the Chinese Ministry of Education ; 111'' Project of the Ministry of Education of China
Funding ProjectNational Basic Research Program of the Ministry of Science and Technology of China[2014CB548200] ; National Basic Research Program of the Ministry of Science and Technology of China[2015CB554503] ; National Natural Science Foundation of China[91732107] ; National Natural Science Foundation of China[81571067] ; National Natural Science Foundation of China[81521063] ; National Natural Science Foundation of China[31872774] ; National Natural Science Foundation of China[81974166] ; Beijing Natural Science Foundation[5182013] ; Key Project of the Chinese Ministry of Education[109003] ; 111'' Project of the Ministry of Education of China[B07001]
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000495045400016
PublisherCELL PRESS
WOS KeywordMEDIAL PREFRONTAL CORTEX ; FUNCTIONAL CONNECTIVITY ; NEUROPATHIC PAIN ; ADULT NEUROGENESIS ; BACK-PAIN ; BRAIN ; NEURONS ; STIMULATION ; TRANSITION ; PATHWAYS
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30789
Collection中国科学院心理健康重点实验室
Corresponding AuthorWan, You; Yi, Ming
Affiliation1.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
5.Peking Univ, Key Lab Neurosci, Natl Hlth Commiss, Minist Educ, Beijing 100083, Peoples R China
6.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China
Recommended Citation
GB/T 7714
Ma, Longyu,Yue, Lupeng,Zhang, Yuqi,et al. Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation[J]. CELL REPORTS,2019,29(6):1579-+.
APA Ma, Longyu.,Yue, Lupeng.,Zhang, Yuqi.,Wang, Yue.,Han, Bingxuan.,...&Yi, Ming.(2019).Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation.CELL REPORTS,29(6),1579-+.
MLA Ma, Longyu,et al."Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation".CELL REPORTS 29.6(2019):1579-+.
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