PSYCH OpenIR  > 中国科学院心理健康重点实验室
Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia
Lang, Xiaoe1; Trihn, Tammy H.2; Wu, Hanjing Emily2; Tong, Yongsheng3; Xiu, Meihong3; Zhang, Xiang Yang4,5
First AuthorLang, Xiaoe
Correspondent Emaillangxiaoe@yeah.net ; xiumeihong97@163.com ; zhangxy@psych.ac.cn
Contribution Rank4
Abstract

Patients with schizophrenia (SCZ) exhibit higher suicide rates than the general population. However, the molecular mechanism remains poorly understood. Tumor necrosis factor (TNF)-alpha polymorphisms have been repeatedly indicated to play a pathogenetic role in various mental disorders, but none of these studies focused on the susceptibility to suicidal behavior in SCZ. We recruited 1087 chronic inpatients with SCZ and 576 controls to assess the psychopathological symptoms of SCZ using the Positive and Negative Syndrome Scale scales. We selected 2 polymorphisms (-308G>A and -1031C>T) in the TNF-alpha gene and analyzed their associations with SCZ and suicide. Our results showed that TNF-alpha -308G>A and -1031C>T were not related to SCZ and suicide. However, we found that suicide attempters with the C allele carriers exhibited suicidal behaviors significantly later than those with TT genotype in the SCZ patients. The haplotype containing the T allele of the -1031 was significantly associated with the age of suicide initiation. Further logistic regression analysis showed that -1031C>T interacted with psychopathological symptoms and drinking, age of smoking, and related to the initiation age of suicide attempts. Our study demonstrated that the TNF-alpha variants may affect the age at which suicide attempts started among SCZ suicide attempters.

Keywordschizophrenia genotype suicide TNF-alpha association
2020-01-31
Language英语
DOI10.18632/aging.102692
Source PublicationAGING-US
ISSN1945-4589
Volume12Issue:2Pages:1433-1445
Subtypearticle
Indexed BySCI
Funding ProjectKey Research Project in Shanxi Province[201803D31098] ; Wu Jieping Medical Foundation[320.6750.18336] ; National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509]
PublisherIMPACT JOURNALS LLC
WOS KeywordNECROSIS-FACTOR-ALPHA ; ADMIXTURE ANALYSIS ; GENE POLYMORPHISM ; PREFRONTAL CORTEX ; BIPOLAR DISORDER ; CYTOKINE LEVELS ; NO ASSOCIATION ; METAANALYSIS ; PROMOTER ; MARKERS
WOS Research AreaCell Biology ; Geriatrics & Gerontology
WOS SubjectCell Biology ; Geriatrics & Gerontology
WOS IDWOS:000511120700027
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30834
Collection中国科学院心理健康重点实验室
Corresponding AuthorLang, Xiaoe; Xiu, Meihong; Zhang, Xiang Yang
Affiliation1.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China
2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Lang, Xiaoe,Trihn, Tammy H.,Wu, Hanjing Emily,et al. Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia[J]. AGING-US,2020,12(2):1433-1445.
APA Lang, Xiaoe,Trihn, Tammy H.,Wu, Hanjing Emily,Tong, Yongsheng,Xiu, Meihong,&Zhang, Xiang Yang.(2020).Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia.AGING-US,12(2),1433-1445.
MLA Lang, Xiaoe,et al."Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia".AGING-US 12.2(2020):1433-1445.
Files in This Item:
File Name/Size DocType Version Access License
Association between (616KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lang, Xiaoe]'s Articles
[Trihn, Tammy H.]'s Articles
[Wu, Hanjing Emily]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lang, Xiaoe]'s Articles
[Trihn, Tammy H.]'s Articles
[Wu, Hanjing Emily]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lang, Xiaoe]'s Articles
[Trihn, Tammy H.]'s Articles
[Wu, Hanjing Emily]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.