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Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia
Lang, Xiaoe1; Trihn, Tammy H.2; Wu, Hanjing Emily2; Tong, Yongsheng3; Xiu, Meihong3; Zhang, Xiang Yang4,5
First AuthorLang, Xiaoe
2020-01-31
Source PublicationAGING-US
Correspondent Emaillangxiaoe@yeah.net ; xiumeihong97@163.com ; zhangxy@psych.ac.cn
ISSN1945-4589
Subtypearticle
Volume12Issue:2Pages:1433-1445
Contribution Rank4
Abstract

Patients with schizophrenia (SCZ) exhibit higher suicide rates than the general population. However, the molecular mechanism remains poorly understood. Tumor necrosis factor (TNF)-alpha polymorphisms have been repeatedly indicated to play a pathogenetic role in various mental disorders, but none of these studies focused on the susceptibility to suicidal behavior in SCZ. We recruited 1087 chronic inpatients with SCZ and 576 controls to assess the psychopathological symptoms of SCZ using the Positive and Negative Syndrome Scale scales. We selected 2 polymorphisms (-308G>A and -1031C>T) in the TNF-alpha gene and analyzed their associations with SCZ and suicide. Our results showed that TNF-alpha -308G>A and -1031C>T were not related to SCZ and suicide. However, we found that suicide attempters with the C allele carriers exhibited suicidal behaviors significantly later than those with TT genotype in the SCZ patients. The haplotype containing the T allele of the -1031 was significantly associated with the age of suicide initiation. Further logistic regression analysis showed that -1031C>T interacted with psychopathological symptoms and drinking, age of smoking, and related to the initiation age of suicide attempts. Our study demonstrated that the TNF-alpha variants may affect the age at which suicide attempts started among SCZ suicide attempters.

Keywordschizophrenia genotype suicide TNF-alpha association
DOI10.18632/aging.102692
Indexed BySCI
Language英语
Funding OrganizationKey Research Project in Shanxi Province ; Wu Jieping Medical Foundation ; National Natural Science Foundation of China
Funding ProjectKey Research Project in Shanxi Province[201803D31098] ; Wu Jieping Medical Foundation[320.6750.18336] ; National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509]
WOS Research AreaCell Biology ; Geriatrics & Gerontology
WOS SubjectCell Biology ; Geriatrics & Gerontology
WOS IDWOS:000511120700027
PublisherIMPACT JOURNALS LLC
WOS KeywordNECROSIS-FACTOR-ALPHA ; ADMIXTURE ANALYSIS ; GENE POLYMORPHISM ; PREFRONTAL CORTEX ; BIPOLAR DISORDER ; CYTOKINE LEVELS ; NO ASSOCIATION ; METAANALYSIS ; PROMOTER ; MARKERS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30834
Collection中国科学院心理健康重点实验室
Corresponding AuthorLang, Xiaoe; Xiu, Meihong; Zhang, Xiang Yang
Affiliation1.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China
2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Lang, Xiaoe,Trihn, Tammy H.,Wu, Hanjing Emily,et al. Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia[J]. AGING-US,2020,12(2):1433-1445.
APA Lang, Xiaoe,Trihn, Tammy H.,Wu, Hanjing Emily,Tong, Yongsheng,Xiu, Meihong,&Zhang, Xiang Yang.(2020).Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia.AGING-US,12(2),1433-1445.
MLA Lang, Xiaoe,et al."Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia".AGING-US 12.2(2020):1433-1445.
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