PSYCH OpenIR  > 健康与遗传心理学研究室
Factor analysis of electroacupuncture and selective serotonin reuptake inhibitors for major depressive disorder: an 8-week controlled clinical trial
Yang, Xinjing1,2; Gong, Weijun2; Ma, Xuehong3; Wang, Sihan1; Wang, Xueqin4; Guo, Tianwei5; Guo, Zhuo6; Sun, Yang1; Li, Jing7; Zhao, Bingcong1; Tu, Ya1
First AuthorYang, Xinjing
Correspondent Emailtuyab@263.net
2020-02-01
Source PublicationACUPUNCTURE IN MEDICINE
ISSN0964-5284
Subtypearticle
Volume38Issue:1Pages:45-52
Contribution Rank7
Abstract

Background: There is evidence supporting electroacupuncture (EA) for the treatment of major depressive disorder (MDD), but its characteristics have not been well investigated. Objective: To investigate the effectiveness and characteristics of EA in MDD. Methods: 60 subjects were enrolled-35 in the EA group and 25 in the selective serotonin reuptake inhibitor (SSRI) group based on their preferences-in an 8-week non-randomised controlled clinical trial. The 24-item Hamilton depression rating scale (HAMD-24) and clinical global impression (CGI) were adopted for clinical assessment. The Columbia suicide severity rating scale and adverse event form were used to measure safety and tolerability. The characteristics of EA and SSRIs were compared by analysing seven factors of the HAMD-24. Results: There was no significant difference between the two groups in terms of HAMD-24 response rate after intervention (P>0.05). Patients treated with EA demonstrated a significant reduction in CGI scores (P<0.05) with fewer adverse events compared with SSRIs (P<0.01). Although HAMD-24 factor analysis showed both EA and SSRIs could improve factor scores in cognitive impairment, diurnal variation, retardation, sleep disturbance, anxiety/somatisation and feelings of despair, EA showed greater improvement in anxiety/somatisation and feelings of despair than SSRIs (P<0.05). Conclusions: There was no significant difference between EA and SSRIs in the treatment of MDD with respect to our primary outcome. However, as a potential therapy for MDD, EA appeared to result in greater symptom improvement than SSRI treatment with respect to anxiety/somatisation and feelings of despair. The results of this secondary analysis should be interpreted cautiously given the inherent issues of multiple testing.

Keywordelectroacupuncture major depressive disorder Hamilton depression rating scale anxiety somatisation selective serotonin reuptake inhibitors
DOI10.1136/acupmed-2017-011412
Indexed BySCI
Language英语
Funding OrganizationProject of Scientific and Technological Achievements of Ten Major Diseases in the Capital
Funding ProjectProject of Scientific and Technological Achievements of Ten Major Diseases in the Capital[Z121100005512024]
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000513154200005
PublisherSAGE PUBLICATIONS LTD
WOS KeywordACUPUNCTURE ; ANTIDEPRESSANTS ; ENHANCE ; SCALE ; RATS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30837
Collection健康与遗传心理学研究室
Corresponding AuthorTu, Ya
Affiliation1.Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China
2.Capital Med Univ, Chinese Med Rehabil Ctr, Beijing Rehabil Hosp, Beijing, Peoples R China
3.Beijing Univ Chinese Med, Dongfang Hosp, Acupuncture Moxibust Dept, Clin Med Coll, Beijing, Peoples R China
4.Peking Univ, Psychiat Dept, Hosp 6, Beijing, Peoples R China
5.Amer Acad Acupuncture & Oriental Med, DAOM Program, Roseville, MN USA
6.Hebei Med Univ, Sch Chinese Integrat Med, Shijiazhuang, Hebei, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yang, Xinjing,Gong, Weijun,Ma, Xuehong,et al. Factor analysis of electroacupuncture and selective serotonin reuptake inhibitors for major depressive disorder: an 8-week controlled clinical trial[J]. ACUPUNCTURE IN MEDICINE,2020,38(1):45-52.
APA Yang, Xinjing.,Gong, Weijun.,Ma, Xuehong.,Wang, Sihan.,Wang, Xueqin.,...&Tu, Ya.(2020).Factor analysis of electroacupuncture and selective serotonin reuptake inhibitors for major depressive disorder: an 8-week controlled clinical trial.ACUPUNCTURE IN MEDICINE,38(1),45-52.
MLA Yang, Xinjing,et al."Factor analysis of electroacupuncture and selective serotonin reuptake inhibitors for major depressive disorder: an 8-week controlled clinical trial".ACUPUNCTURE IN MEDICINE 38.1(2020):45-52.
Files in This Item:
File Name/Size DocType Version Access License
Factor analysis of e(754KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Xinjing]'s Articles
[Gong, Weijun]'s Articles
[Ma, Xuehong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Xinjing]'s Articles
[Gong, Weijun]'s Articles
[Ma, Xuehong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Xinjing]'s Articles
[Gong, Weijun]'s Articles
[Ma, Xuehong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.