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Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia
Miao, Qi1,2,3,4; Pu, Chengcheng1,2,3,4; Wang, Zhijiang1,2,3,4; Yan, Chao-Gan5,6,7; Shi, Chuan1,2,3,4; Cao, Qingjiu1,2,3,4; Wang, Xijin8; Cheng, Zhang1,2,3,4; Han, Xue1,2,3,4; Yang, Lei1,2,3,4; Lai, Yunyao9; Yuan, Yanbo1,2,3,4; Ma, Hong1,2,3,4; Li, Keqing10; Hong, Nan9; Yu, Xin1,2,3,4
First AuthorQi Miao, MD
2020-02-06
Source PublicationCANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
Correspondent Emailyuxin@bjmu.edu.cn ; hongnan@bjmu.edu.cn
ISSN0706-7437
Subtypearticle
Pages10
Contribution Rank5
Abstract

Objective: To explore the effect of long-term antipsychotics use on the strength of functional connectivity (FC) in the brains of patients with chronic schizophrenia. Method: We collected resting-state functional magnetic resonance imaging from 15 patients with continuously treated chronic schizophrenia (TCS), 19 patients with minimally TCS (MTCS), and 20 healthy controls (HCs). Then, we evaluated and compared the whole-brain FC strength (FCS; including full-range, short-range, and long-range FCS) among patients with TCS, MTCS, and HCs. Results: Patients with TCS and MTCS showed reduced full-/short-range FC compared with the HCs. No significant differences in the whole-brain FCS (including full-range, short-range, and long-range FCS) or clinical characteristics were identified between patients with TCS and MTCS. Additionally, the FCS in the right fusiform gyrus, right inferior temporal gyrus, and right inferior occipital gyrus negatively correlated with the duration of illness and positively correlated with onset age across all patients with chronic schizophrenia. Conclusions: Regardless of the long-term use of antipsychotics, patients with chronic schizophrenia show decreased FC compared with healthy individuals. For some patients with chronic schizophrenia, the influence of long-term and minimal/short-term antipsychotic exposure on resting-state FC was similar. The decreased full- and short-range FCS in the right fusiform gyrus, right inferior temporal gyrus, and right inferior occipital gyrus may be an ongoing pathological process that is not altered by antipsychotic interventions in patients with chronic schizophrenia. Large-sample, long-term follow-up studies are still needed for further exploration.

Keywordchronic schizophrenia antipsychotics long-term resting-state functional magnetic resonance imaging functional connectivity
DOI10.1177/0706743720904815
Indexed BySCI
Language英语
Funding OrganizationBeijing Science and Technology Commission
Funding ProjectBeijing Science and Technology Commission[D171100007017002]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000512246400001
PublisherSAGE PUBLICATIONS INC
WOS KeywordUNMEDICATED PATIENTS ; GLOBAL SIGNAL ; FMRI ; PSYCHOSIS ; NETWORKS ; PHASE ; RECOGNITION ; MEDICATION ; MECHANISMS ; DOPAMINE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30843
Collection中国科学院行为科学重点实验室
Corresponding AuthorHong, Nan; Yu, Xin
Affiliation1.Peking Univ, Hosp 6, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, 51 Huayuanbeilu, Beijing 100191, Peoples R China
3.Peking Univ, NHC Key Lab Mental Hlth, Beijing, Peoples R China
4.Peking Univ, Natl Clin Res Ctr Mental Hlth Disorders, Hosp 6, Beijing, Peoples R China
5.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
8.First Psychiat Hosp Harbin, Harbin, Heilongjiang, Peoples R China
9.Peking Univ, Peoples Hosp, Dept Radiol, 11 Xizhimen South St, Beijing, Peoples R China
10.Sixth Peoples Hosp Hebei Prov, Baoding, Peoples R China
Recommended Citation
GB/T 7714
Miao, Qi,Pu, Chengcheng,Wang, Zhijiang,et al. Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia[J]. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE,2020:10.
APA Miao, Qi.,Pu, Chengcheng.,Wang, Zhijiang.,Yan, Chao-Gan.,Shi, Chuan.,...&Yu, Xin.(2020).Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia.CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE,10.
MLA Miao, Qi,et al."Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia".CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE (2020):10.
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