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Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder
Mu, Li1; Lin, Yezhe2; Huang, Xingbing3,4; Ning, Yuping3,4; Wu, Fengchun3,4; Zhang, Xiang Yang4,5
第一作者Mu, Li
通讯作者邮箱13580380071@163.com
心理所单位排序5
摘要

Objective Sex differences in bipolar disorder are well recognized but little attention has been paid to sex differences in homocysteine or hyperhomocysteinemia in bipolar patients. This study compared gender differences in homocysteine levels and rates of hyperhomocysteinemia in Chinese inpatients with bipolar disorder. Methods A total of 198 BD patients and 84 healthy controls were enrolled. The Young Mania Rating Scale, Hamilton Depression Rating Scale, and the Clinical Global Impressions-Severity scale were used to assess the affective symptomatology. Fasting plasma Hcy levels were measured by high-performance liquid chromatography. Results Men had higher homocysteine levels than women and the prevalence of hyperhomocysteinemia in male patients was approximately twice that in female patients. Logistic regression analyses showed that HHcy was associated with less frequent use of valproate in males and being overweight in females. Further correlation analysis and multivariate regression analysis demonstrated that Hcy levels were inversely correlated with valproate treatment in men and positively associated with overweight in women. Conclusions In bipolar patients, there are significant differences between sexes in the levels of homocysteine and prevalence of hyperhomocysteinemia. This appears to be associated with lower prevalence of valproate prescribing in men and with being overweight in women.

关键词bipolar disorder homocysteine overweight sex difference valproate
2020-02-13
语种英语
DOI10.1002/hup.2724
发表期刊HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
ISSN0885-6222
页码8
期刊论文类型article
收录类别SCI
资助项目Science and Technology Program of Guangdong[2016A020216004]
出版者WILEY
WOS关键词METHYLENETETRAHYDROFOLATE REDUCTASE GENE ; ELEVATED HOMOCYSTEINE LEVELS ; PLASMA HOMOCYSTEINE ; SERUM HOMOCYSTEINE ; GENDER-DIFFERENCES ; EPILEPTIC PATIENTS ; ASSOCIATION ; VALPROATE ; POLYMORPHISMS ; OBESITY
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS类目Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS记录号WOS:000512980800001
资助机构Science and Technology Program of Guangdong
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/30862
专题中国科学院心理健康重点实验室
通讯作者Wu, Fengchun; Zhang, Xiang Yang
作者单位1.Liaoning Normal Univ, Res Ctr Brain & Cognit Neurosci, Dalian, Peoples R China
2.Univ Rochester, Med Ctr, Dept Psychiat, Rochester, NY 14642 USA
3.Guangzhou Med Univ, Dept Psychiat, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China
4.Guangdong Engn Technol Res Ctr Translat Med Menta, Dept Psychiat, Guangzhou, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Mu, Li,Lin, Yezhe,Huang, Xingbing,et al. Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2020:8.
APA Mu, Li,Lin, Yezhe,Huang, Xingbing,Ning, Yuping,Wu, Fengchun,&Zhang, Xiang Yang.(2020).Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,8.
MLA Mu, Li,et al."Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020):8.
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