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Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder
Mu, Li1; Lin, Yezhe2; Huang, Xingbing3,4; Ning, Yuping3,4; Wu, Fengchun3,4; Zhang, Xiang Yang4,5
First AuthorMu, Li
Correspondent Email13580380071@163.com
Contribution Rank5
Abstract

Objective Sex differences in bipolar disorder are well recognized but little attention has been paid to sex differences in homocysteine or hyperhomocysteinemia in bipolar patients. This study compared gender differences in homocysteine levels and rates of hyperhomocysteinemia in Chinese inpatients with bipolar disorder. Methods A total of 198 BD patients and 84 healthy controls were enrolled. The Young Mania Rating Scale, Hamilton Depression Rating Scale, and the Clinical Global Impressions-Severity scale were used to assess the affective symptomatology. Fasting plasma Hcy levels were measured by high-performance liquid chromatography. Results Men had higher homocysteine levels than women and the prevalence of hyperhomocysteinemia in male patients was approximately twice that in female patients. Logistic regression analyses showed that HHcy was associated with less frequent use of valproate in males and being overweight in females. Further correlation analysis and multivariate regression analysis demonstrated that Hcy levels were inversely correlated with valproate treatment in men and positively associated with overweight in women. Conclusions In bipolar patients, there are significant differences between sexes in the levels of homocysteine and prevalence of hyperhomocysteinemia. This appears to be associated with lower prevalence of valproate prescribing in men and with being overweight in women.

Keywordbipolar disorder homocysteine overweight sex difference valproate
2020-02-13
Language英语
DOI10.1002/hup.2724
Source PublicationHUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
ISSN0885-6222
Pages8
Subtypearticle
Indexed BySCI
Funding ProjectScience and Technology Program of Guangdong[2016A020216004]
PublisherWILEY
WOS KeywordMETHYLENETETRAHYDROFOLATE REDUCTASE GENE ; ELEVATED HOMOCYSTEINE LEVELS ; PLASMA HOMOCYSTEINE ; SERUM HOMOCYSTEINE ; GENDER-DIFFERENCES ; EPILEPTIC PATIENTS ; ASSOCIATION ; VALPROATE ; POLYMORPHISMS ; OBESITY
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS SubjectClinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS IDWOS:000512980800001
Funding OrganizationScience and Technology Program of Guangdong
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30862
Collection中国科学院心理健康重点实验室
Corresponding AuthorWu, Fengchun; Zhang, Xiang Yang
Affiliation1.Liaoning Normal Univ, Res Ctr Brain & Cognit Neurosci, Dalian, Peoples R China
2.Univ Rochester, Med Ctr, Dept Psychiat, Rochester, NY 14642 USA
3.Guangzhou Med Univ, Dept Psychiat, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China
4.Guangdong Engn Technol Res Ctr Translat Med Menta, Dept Psychiat, Guangzhou, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Mu, Li,Lin, Yezhe,Huang, Xingbing,et al. Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2020:8.
APA Mu, Li,Lin, Yezhe,Huang, Xingbing,Ning, Yuping,Wu, Fengchun,&Zhang, Xiang Yang.(2020).Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,8.
MLA Mu, Li,et al."Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020):8.
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