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Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study
Wang, Yun1,2,3; Yan, Kai-Juan1,2,3; Fan, Chen-Xiao4; Luo, Xiao-Nian1,2,3; Zhou, Yuan1,2,3,5,6,7
First AuthorWang, Yun
Correspondent Emailzhouyuan@psych.ac.cn
2019-12-30
Source PublicationBMC NEUROSCIENCE
ISSN1471-2202
Subtypearticle
Volume20Issue:1Pages:10
Contribution Rank5
Abstract

Background The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered functional architecture of the nucleus accumbens (NAc) during resting state. NAc contains different subdivisions and they may play different roles in addiction. The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the NAc subdivisions in amphetamine-type stimulant abusers (ATSAs). Methods The present study recruited 17 male ATSAs and 22 healthy male controls. All the subjects underwent resting-state functional magnetic resonance imaging (fMRI) with their eyes closed. The NAc was divided into core-like and shell-like subdivisions. We used seed-based resting-state functional connectivity (RSFC) analyses to identify differences in brain functional architecture between ATSAs and healthy controls (HCs). Results ATSAs had lower positive RSFCs with all of the NAc subdivisions over the left orbital part of superior frontal gyrus and higher positive RSFCs with the NAc subdivisions over the left opercular part of inferior frontal gyrus than HCs, which indicates common abnormalities across the NAc subdivisions in ATSAs. In addition, the RSFCs between the NAc subdivisions and the left orbital part of superior frontal gyrus were negatively correlated with the addiction severity in ATSAs. Conclusion These results provide evidence that there are common RSFC patterns of the NAc subdivisions in ATSAs. The abnormality indicated by disrupted functional connectivity between the NAc subdivisions and prefrontal cortex suggests abnormal interaction between the rewarding process and cognitive control in ATSAs. Our results shed insight on the neurobiological mechanisms of ATSA and suggest potential novel therapeutic targets for treatment and intervention of ATSAs.

KeywordResting-state functional connectivity Amphetamine-type stimulants abuse Nucleus accumbens Orbitofrontal cortex Inferior frontal gyrus
DOI10.1186/s12868-019-0548-y
Indexed BySCI
Language英语
Funding OrganizationNational Key Technology R&D Program in the 12th Five-Year Plan of China
Funding ProjectNational Key Technology R&D Program in the 12th Five-Year Plan of China[2012BAI01B07]
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000511996200001
PublisherBMC
WOS KeywordRESPONSE-INHIBITION ; COGNITIVE CONTROL ; FRONTOSTRIATAL CIRCUITS ; CINGULATE CORTEX ; DRUG-ADDICTION ; BRAIN ; REWARD ; NEUROBIOLOGY ; ASSOCIATION ; INFORMATION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30874
Collection中国科学院行为科学重点实验室
Corresponding AuthorZhou, Yuan
Affiliation1.Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
2.Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
3.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
4.Second Hosp Jinhua City, Jinhua, Zhejiang, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yun,Yan, Kai-Juan,Fan, Chen-Xiao,et al. Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study[J]. BMC NEUROSCIENCE,2019,20(1):10.
APA Wang, Yun,Yan, Kai-Juan,Fan, Chen-Xiao,Luo, Xiao-Nian,&Zhou, Yuan.(2019).Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study.BMC NEUROSCIENCE,20(1),10.
MLA Wang, Yun,et al."Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study".BMC NEUROSCIENCE 20.1(2019):10.
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