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Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles
Ijaz, Sahar1; Mohammed, Ibrahim1; Gholaminejhad, Morteza1; Mokhtari, Tahmineh2,3; Akbari, Mohammad1; Hassanzadeh, Gholamreza1
第一作者Sahar Ijaz
通讯作者邮箱gholamreza hassanzadeh (hassanzadeh@tums.ac.ir)
心理所单位排序2
摘要

Background The upregulation of TNF-alpha, IL-1 beta, IL-18, and IL-6 exacerbates the spinal cord injury by amplifying the neuroinflammation. Impeding the release and activation of these cytokines can stop the progression of lesion and promote healing. Modulating the inflammatory response with subventricular zone-derived extracellular vesicles (SVZ-EVs) is one highly promising approach. Methods and materials SVZ tissue was cultured and EVs were prepared, isolated, and injected intrathecal, in spinal cord-injured (SCI) rats. BBB locomotor scoring, qRT-PCR, Western Blot, H&E, and Nissl staining techniques were applied to record the outcomes. Results The intracisternally injected SVZ-EVs significantly decreased the gene and protein expression of TNF-alpha, IL-1 beta, IL-18, and IL-6, prevented extensive tissue damage, allowed healing, and improved the hind limb motor function in SCI models. Conclusion The results of the present study showed that SVZ-EVs therapy ameliorate inflammation, tissue damage, and motor deficit in traumatic spinal cord injury.

关键词Subventricular zone Extracellular vesicles Spinal cord injury Inflammation Pro-inflammatory cytokines Locomotor activity Rat
2020-03-01
语种英语
DOI10.1007/s12031-019-01437-2
发表期刊JOURNAL OF MOLECULAR NEUROSCIENCE
ISSN0895-8696
卷号70期号:3页码:458-466
期刊论文类型article
收录类别SCI
出版者HUMANA PRESS INC
WOS关键词NEURAL STEM-CELLS ; EXOSOMES ; APOPTOSIS ; RECOVERY ; FUTURE
WOS研究方向Biochemistry & Molecular Biology ; Neurosciences & Neurology
WOS类目Biochemistry & Molecular Biology ; Neurosciences
WOS记录号WOS:000513276100014
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/30877
专题中国科学院心理健康重点实验室
通讯作者Hassanzadeh, Gholamreza
作者单位1.Univ Tehran Med Sci, Sch Med, Dept Anat, Tehran, Iran
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
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GB/T 7714
Ijaz, Sahar,Mohammed, Ibrahim,Gholaminejhad, Morteza,et al. Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2020,70(3):458-466.
APA Ijaz, Sahar,Mohammed, Ibrahim,Gholaminejhad, Morteza,Mokhtari, Tahmineh,Akbari, Mohammad,&Hassanzadeh, Gholamreza.(2020).Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles.JOURNAL OF MOLECULAR NEUROSCIENCE,70(3),458-466.
MLA Ijaz, Sahar,et al."Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles".JOURNAL OF MOLECULAR NEUROSCIENCE 70.3(2020):458-466.
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