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Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles | |
Ijaz, Sahar1; Mohammed, Ibrahim1; Gholaminejhad, Morteza1; Mokhtari, Tahmineh2,3; Akbari, Mohammad1; Hassanzadeh, Gholamreza1 | |
第一作者 | Sahar Ijaz |
通讯作者邮箱 | gholamreza hassanzadeh (hassanzadeh@tums.ac.ir) |
心理所单位排序 | 2 |
摘要 | Background The upregulation of TNF-alpha, IL-1 beta, IL-18, and IL-6 exacerbates the spinal cord injury by amplifying the neuroinflammation. Impeding the release and activation of these cytokines can stop the progression of lesion and promote healing. Modulating the inflammatory response with subventricular zone-derived extracellular vesicles (SVZ-EVs) is one highly promising approach. Methods and materials SVZ tissue was cultured and EVs were prepared, isolated, and injected intrathecal, in spinal cord-injured (SCI) rats. BBB locomotor scoring, qRT-PCR, Western Blot, H&E, and Nissl staining techniques were applied to record the outcomes. Results The intracisternally injected SVZ-EVs significantly decreased the gene and protein expression of TNF-alpha, IL-1 beta, IL-18, and IL-6, prevented extensive tissue damage, allowed healing, and improved the hind limb motor function in SCI models. Conclusion The results of the present study showed that SVZ-EVs therapy ameliorate inflammation, tissue damage, and motor deficit in traumatic spinal cord injury. |
关键词 | Subventricular zone Extracellular vesicles Spinal cord injury Inflammation Pro-inflammatory cytokines Locomotor activity Rat |
2020-03-01 | |
语种 | 英语 |
DOI | 10.1007/s12031-019-01437-2 |
发表期刊 | JOURNAL OF MOLECULAR NEUROSCIENCE |
ISSN | 0895-8696 |
卷号 | 70期号:3页码:458-466 |
期刊论文类型 | article |
收录类别 | SCI |
出版者 | HUMANA PRESS INC |
WOS关键词 | NEURAL STEM-CELLS ; EXOSOMES ; APOPTOSIS ; RECOVERY ; FUTURE |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences |
WOS记录号 | WOS:000513276100014 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30877 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Hassanzadeh, Gholamreza |
作者单位 | 1.Univ Tehran Med Sci, Sch Med, Dept Anat, Tehran, Iran 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Ijaz, Sahar,Mohammed, Ibrahim,Gholaminejhad, Morteza,et al. Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2020,70(3):458-466. |
APA | Ijaz, Sahar,Mohammed, Ibrahim,Gholaminejhad, Morteza,Mokhtari, Tahmineh,Akbari, Mohammad,&Hassanzadeh, Gholamreza.(2020).Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles.JOURNAL OF MOLECULAR NEUROSCIENCE,70(3),458-466. |
MLA | Ijaz, Sahar,et al."Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles".JOURNAL OF MOLECULAR NEUROSCIENCE 70.3(2020):458-466. |
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Modulating Pro-infla(9567KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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