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Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles
Ijaz, Sahar1; Mohammed, Ibrahim1; Gholaminejhad, Morteza1; Mokhtari, Tahmineh2,3; Akbari, Mohammad1; Hassanzadeh, Gholamreza1
First AuthorSahar Ijaz
Correspondent Emailgholamreza hassanzadeh (hassanzadeh@tums.ac.ir)
2020-03-01
Source PublicationJOURNAL OF MOLECULAR NEUROSCIENCE
ISSN0895-8696
Subtypearticle
Volume70Issue:3Pages:458-466
Contribution Rank2
Abstract

Background The upregulation of TNF-alpha, IL-1 beta, IL-18, and IL-6 exacerbates the spinal cord injury by amplifying the neuroinflammation. Impeding the release and activation of these cytokines can stop the progression of lesion and promote healing. Modulating the inflammatory response with subventricular zone-derived extracellular vesicles (SVZ-EVs) is one highly promising approach. Methods and materials SVZ tissue was cultured and EVs were prepared, isolated, and injected intrathecal, in spinal cord-injured (SCI) rats. BBB locomotor scoring, qRT-PCR, Western Blot, H&E, and Nissl staining techniques were applied to record the outcomes. Results The intracisternally injected SVZ-EVs significantly decreased the gene and protein expression of TNF-alpha, IL-1 beta, IL-18, and IL-6, prevented extensive tissue damage, allowed healing, and improved the hind limb motor function in SCI models. Conclusion The results of the present study showed that SVZ-EVs therapy ameliorate inflammation, tissue damage, and motor deficit in traumatic spinal cord injury.

KeywordSubventricular zone Extracellular vesicles Spinal cord injury Inflammation Pro-inflammatory cytokines Locomotor activity Rat
DOI10.1007/s12031-019-01437-2
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences
WOS IDWOS:000513276100014
PublisherHUMANA PRESS INC
WOS KeywordNEURAL STEM-CELLS ; EXOSOMES ; APOPTOSIS ; RECOVERY ; FUTURE
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30877
Collection中国科学院心理健康重点实验室
Corresponding AuthorHassanzadeh, Gholamreza
Affiliation1.Univ Tehran Med Sci, Sch Med, Dept Anat, Tehran, Iran
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Ijaz, Sahar,Mohammed, Ibrahim,Gholaminejhad, Morteza,et al. Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2020,70(3):458-466.
APA Ijaz, Sahar,Mohammed, Ibrahim,Gholaminejhad, Morteza,Mokhtari, Tahmineh,Akbari, Mohammad,&Hassanzadeh, Gholamreza.(2020).Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles.JOURNAL OF MOLECULAR NEUROSCIENCE,70(3),458-466.
MLA Ijaz, Sahar,et al."Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles".JOURNAL OF MOLECULAR NEUROSCIENCE 70.3(2020):458-466.
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