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Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats
Jiang, Feng-Ze1,2; Zheng, Wei1,2; Wu, Chao1,2; Li, Yonghui1,2; Shen, Fang1,2; Liang, Jing1,2; Li, Ming3; Zhang, Jian-Jun1,2; Sui, Nan1,2
First AuthorJiang, Feng-Ze
Correspondent Emailzhangjj@psych.ac.cn ; suin@psych.ac.cn
Contribution Rank1
Abstract

The development of opioid addiction involves DNA methylation. Accordingly, the DNA demethylation, induced by ten-eleven translocation (Tet) enzymes, may represent a novel approach to prevent opioid addiction. The present study examined the role of TET1 and TET3 in the development of morphine-seeking behavior in rats. We showed that 1 day of morphine self-administration (SA) training upregulated TET3 but not TET1 expression in the hippocampal CA1. With 7 days of morphine SA training, the expression of TET3 in the CA1 returned to the baseline level, while the TET1 expression was downregulated. No change of TET1 and TET3 in the nucleus accumbens shell was observed in morphine SA trained rats, or in the yoked morphine rats, or in rats trained for saccharin SA. Furthermore, we found that knocking down TET3 expression in the CA1 accelerated the acquisition of morphine SA, while overexpression of the catalytic domain of TET1 in the CA1 attenuated the acquisition. Together, these findings suggest that TET1 and TET3 in the CA1 are important epigenetic modulators involved in the morphine-seeking behavior and provide a new strategy in the treatment of opioid addiction.

Keywordacquisition hippocampal CA1 morphine self-administration TET1 TET3
2020-02-07
Language英语
DOI10.1111/adb.12875
Source PublicationADDICTION BIOLOGY
ISSN1355-6215
Pages11
Subtypearticle
Indexed BySCI
Funding ProjectMinistry of Science and Technology of the People's Republic of China[2015CB553501] ; National Natural Science Foundation of China[31400880] ; National Natural Science Foundation of China[31871111] ; National Natural Science Foundation of China[91332115] ; National Basic Research Program[2015CB553501] ; Key Laboratory of Mental Health, Institute of Psychology, CAS
PublisherWILEY
WOS KeywordNUCLEUS-ACCUMBENS SHELL ; ACTIVE DNA DEMETHYLATION ; INDUCED PLACE PREFERENCE ; MU-OPIOID-RECEPTORS ; MEMORY ; METHYLATION ; ADDICTION ; EXPRESSION ; 5-METHYLCYTOSINE ; RETRIEVAL
WOS Research AreaBiochemistry & Molecular Biology ; Substance Abuse
WOS SubjectBiochemistry & Molecular Biology ; Substance Abuse
WOS IDWOS:000511512100001
QuartileQ1
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30886
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Jian-Jun; Sui, Nan
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Jiang, Feng-Ze,Zheng, Wei,Wu, Chao,et al. Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats[J]. ADDICTION BIOLOGY,2020:11.
APA Jiang, Feng-Ze.,Zheng, Wei.,Wu, Chao.,Li, Yonghui.,Shen, Fang.,...&Sui, Nan.(2020).Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats.ADDICTION BIOLOGY,11.
MLA Jiang, Feng-Ze,et al."Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats".ADDICTION BIOLOGY (2020):11.
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