PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia
Zhou, Yongjie1,2; Li, Yuhuan3; Meng, Yujie3; Wang, Jiesi4; Wu, Fengchun5; Ning, Yuping5; Li, Yi1,2; Cassidy, Ryan M.6; Li, Zezhi7; Zhang, Xiang Yang4
First AuthorZhou, Yongjie
Correspondent Emailzezhi li (lizezhi1981@aliyun.com) ; xiang yang zhang (zhangxy@psych.ac.cn)
2020-02-11
Source PublicationTRANSLATIONAL PSYCHIATRY
ISSN2158-3188
Subtypearticle
Volume10Issue:1Pages:9
Contribution Rank4
Abstract

There is evidence that obesity or higher body mass index is correlated with cognitive impairment in schizophrenia. Recent studies have demonstrated that genetic risk factors, such as the NRG3, are correlated with both elevated BMI and reduced cognitive function. In present study, we aimed to determine whether possession of the NRG3 rs10748842 influences the correlation between elevated BMI and reduced cognitive ability in schizophrenia. To our knowledge, this has never been examined before. A total of 625 inpatients with schizophrenia and 400 controls were recruited. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was performed to assess cognitive function. We used multiple analysis of covariance (MANCOVA), analyses of covariance (ANCOVA), Pearson correlations, partial correlations, and multivariate regression analysis to test the influence of NRG3 rs10748842 on the aforementioned variables. All RBANS five sub-scores and total score were lower in patients than those in controls (all p < 0.001). Patients carrying NRG3 rs10748842 TC + CC heterozygous genotype had lower attention score compared to TT homozygous genotype (adjusted F = 4.77, p = 0.029). BMI was positively associated with language score in patients (beta = 0.387, t = 2.59, p = 0.01). Interestingly, we further found positive association between BMI and language score in TT carriers (partial correlations: r = 0.13, adjusted p = 0.004; multivariate regression: beta = 0.42, t = 2.66, p = 0.008), but not in CT + CC carrier (p > 0.05). Our study demonstrated that NRG3 rs10748842 was associated with cognitive impairments, especially attention performance in schizophrenia. Moreover, NRG3 rs10748842 altered the effect of BMI on cognitive impairments as measured by the RBANS language score in chronic patients with schizophrenia.

DOI10.1038/s41398-020-0746-5
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Shanghai Jiao Tong University Medical Engineering Foundation ; Excellent talent foundation of Shanghai Jiao Tong University School of Medicine ; Science and Technology Program of Guangzhou ; project of Wuhan Municipal Health and Family planning Commission
Funding ProjectNational Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81401127] ; Shanghai Jiao Tong University Medical Engineering Foundation[YG2016MS48] ; Excellent talent foundation of Shanghai Jiao Tong University School of Medicine[19XJ11006] ; Science and Technology Program of Guangzhou[201807010064] ; project of Wuhan Municipal Health and Family planning Commission[WX15C06] ; project of Wuhan Municipal Health and Family planning Commission[WG12A0]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000514256700001
PublisherNATURE PUBLISHING GROUP
WOS KeywordGENOME-WIDE ASSOCIATION ; GENETIC OVERLAP ; OBESITY ; DEFICITS ; RISK ; BMI ; DISORDER ; NRG3 ; NEUROCOGNITION ; PERFORMANCE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30936
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Zezhi; Zhang, Xiang Yang
Affiliation1.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China
2.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Tongji Med Coll, Wuhan, Peoples R China
3.Qingdao Mental Hlth Ctr, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Huiai Hosp, Guangzhou, Peoples R China
6.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
7.Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Neurol, Sch Med, Shanghai, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhou, Yongjie,Li, Yuhuan,Meng, Yujie,et al. Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):9.
APA Zhou, Yongjie.,Li, Yuhuan.,Meng, Yujie.,Wang, Jiesi.,Wu, Fengchun.,...&Zhang, Xiang Yang.(2020).Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia.TRANSLATIONAL PSYCHIATRY,10(1),9.
MLA Zhou, Yongjie,et al."Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia".TRANSLATIONAL PSYCHIATRY 10.1(2020):9.
Files in This Item:
File Name/Size DocType Version Access License
Neuregulin 3 rs10748(468KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhou, Yongjie]'s Articles
[Li, Yuhuan]'s Articles
[Meng, Yujie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, Yongjie]'s Articles
[Li, Yuhuan]'s Articles
[Meng, Yujie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, Yongjie]'s Articles
[Li, Yuhuan]'s Articles
[Meng, Yujie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.