Cognitive Profile of Patients With Mitochondrial Chronic Progressive External Ophthalmoplegia | |
Zhang, Guanyu1,2; Hou, Yue3; Wang, Zhaoxia3; Ye, Zheng4 | |
第一作者 | Zhang, Guanyu |
通讯作者邮箱 | zhaoxia wang drwangzx@163.com ; zheng ye yez@ion.ac.cn |
心理所单位排序 | 1 |
摘要 | Mitochondrial chronic progressive external ophthalmoplegia (CPEO) is a major manifestation of human mitochondrial encephalomyopathies. Previous studies have shown cognitive deficits in patients with mitochondrial diseases. However, these studies often included patients with heterogeneous subtypes of mitochondrial diseases. Here, we aimed to provide a better cognitive profile of patients with CPEO by applying a comprehensive battery of neuropsychological assessments in a pure sample of patients with CPEO. We recruited 28 patients with CPEO (19 women, age 16-62 years) and 38 age- and education-matched healthy control subjects (25 women, age 16-60 years). The neuropsychological assessments covered global cognition and five cognitive domains (executive functions, language, working memory, memory, and visuospatial functions). We found that the patients were impaired in global cognition [Montreal Cognitive Assessment (MoCA)], executive functions [Trail Making Test Part B (TMT-B)], and language [Boston Naming Test (BNT)], but not in working memory, memory or visuospatial functions. Moreover, individual patients' performances in the TMT-B (completion time) were predicted by the severity of non-ophthalmoplegia mitochondrial symptoms/signs [Newcastle Mitochondrial Disease Adult Scale (NMDAS)] and duration of the mitochondrial disease (years). Namely, patients with more severe non-ophthalmoplegia mitochondrial symptoms/signs and a longer disease duration took a longer time to complete the TMT-B. No clinical measures predicted individual patients' performances in the BNT. |
关键词 | mitochondrial chronic progressive external ophthalmoplegia cognition executive functions language working memory memory visuospatial functions |
2020-01-29 | |
语种 | 英语 |
DOI | 10.3389/fneur.2020.00036 |
发表期刊 | FRONTIERS IN NEUROLOGY |
ISSN | 1664-2295 |
卷号 | 11页码:7 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31771216] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | CHINESE VERSION ; ADULTS ; MELAS ; VALIDATION ; DISORDERS ; DEMENTIA ; DEFICITS ; DISEASE ; SCALE |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Clinical Neurology ; Neurosciences |
WOS记录号 | WOS:000514398100001 |
资助机构 | National Natural Science Foundation of China ; Shanghai Municipal Science and Technology Major Project |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30951 |
专题 | 健康与遗传心理学研究室 |
通讯作者 | Wang, Zhaoxia; Ye, Zheng |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Peking Univ, Dept Neurol, Hosp 1, Beijing, Peoples R China 4.Chinese Acad Sci, Key Lab Primate Neurobiol, Inst Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China |
第一作者单位 | 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Zhang, Guanyu,Hou, Yue,Wang, Zhaoxia,et al. Cognitive Profile of Patients With Mitochondrial Chronic Progressive External Ophthalmoplegia[J]. FRONTIERS IN NEUROLOGY,2020,11:7. |
APA | Zhang, Guanyu,Hou, Yue,Wang, Zhaoxia,&Ye, Zheng.(2020).Cognitive Profile of Patients With Mitochondrial Chronic Progressive External Ophthalmoplegia.FRONTIERS IN NEUROLOGY,11,7. |
MLA | Zhang, Guanyu,et al."Cognitive Profile of Patients With Mitochondrial Chronic Progressive External Ophthalmoplegia".FRONTIERS IN NEUROLOGY 11(2020):7. |
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