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Cognitive Profile of Patients With Mitochondrial Chronic Progressive External Ophthalmoplegia
Zhang, Guanyu1,2; Hou, Yue3; Wang, Zhaoxia3; Ye, Zheng4
第一作者Zhang, Guanyu
通讯作者邮箱zhaoxia wang drwangzx@163.com ; zheng ye yez@ion.ac.cn
心理所单位排序1
摘要

Mitochondrial chronic progressive external ophthalmoplegia (CPEO) is a major manifestation of human mitochondrial encephalomyopathies. Previous studies have shown cognitive deficits in patients with mitochondrial diseases. However, these studies often included patients with heterogeneous subtypes of mitochondrial diseases. Here, we aimed to provide a better cognitive profile of patients with CPEO by applying a comprehensive battery of neuropsychological assessments in a pure sample of patients with CPEO. We recruited 28 patients with CPEO (19 women, age 16-62 years) and 38 age- and education-matched healthy control subjects (25 women, age 16-60 years). The neuropsychological assessments covered global cognition and five cognitive domains (executive functions, language, working memory, memory, and visuospatial functions). We found that the patients were impaired in global cognition [Montreal Cognitive Assessment (MoCA)], executive functions [Trail Making Test Part B (TMT-B)], and language [Boston Naming Test (BNT)], but not in working memory, memory or visuospatial functions. Moreover, individual patients' performances in the TMT-B (completion time) were predicted by the severity of non-ophthalmoplegia mitochondrial symptoms/signs [Newcastle Mitochondrial Disease Adult Scale (NMDAS)] and duration of the mitochondrial disease (years). Namely, patients with more severe non-ophthalmoplegia mitochondrial symptoms/signs and a longer disease duration took a longer time to complete the TMT-B. No clinical measures predicted individual patients' performances in the BNT.

关键词mitochondrial chronic progressive external ophthalmoplegia cognition executive functions language working memory memory visuospatial functions
2020-01-29
语种英语
DOI10.3389/fneur.2020.00036
发表期刊FRONTIERS IN NEUROLOGY
ISSN1664-2295
卷号11页码:7
期刊论文类型article
收录类别SCI
资助项目National Natural Science Foundation of China[31771216] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05]
出版者FRONTIERS MEDIA SA
WOS关键词CHINESE VERSION ; ADULTS ; MELAS ; VALIDATION ; DISORDERS ; DEMENTIA ; DEFICITS ; DISEASE ; SCALE
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology ; Neurosciences
WOS记录号WOS:000514398100001
资助机构National Natural Science Foundation of China ; Shanghai Municipal Science and Technology Major Project
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/30951
专题健康与遗传心理学研究室
通讯作者Wang, Zhaoxia; Ye, Zheng
作者单位1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Dept Neurol, Hosp 1, Beijing, Peoples R China
4.Chinese Acad Sci, Key Lab Primate Neurobiol, Inst Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China
第一作者单位中国科学院心理研究所
推荐引用方式
GB/T 7714
Zhang, Guanyu,Hou, Yue,Wang, Zhaoxia,et al. Cognitive Profile of Patients With Mitochondrial Chronic Progressive External Ophthalmoplegia[J]. FRONTIERS IN NEUROLOGY,2020,11:7.
APA Zhang, Guanyu,Hou, Yue,Wang, Zhaoxia,&Ye, Zheng.(2020).Cognitive Profile of Patients With Mitochondrial Chronic Progressive External Ophthalmoplegia.FRONTIERS IN NEUROLOGY,11,7.
MLA Zhang, Guanyu,et al."Cognitive Profile of Patients With Mitochondrial Chronic Progressive External Ophthalmoplegia".FRONTIERS IN NEUROLOGY 11(2020):7.
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