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Obesity in Chinese patients with chronic schizophrenia: Prevalence, clinical correlates and relationship with cognitive deficits
Tian, Yang1,2; Liu, Dianying3; Wang, Dongmei1,2; Wang, Jiesi1,2; Xu, Hang1,2; Dai, Qilong1,2; Andriescue, Elena C.4; Wu, Hanjing E.4; Xiu, Meihong5; Chen, Dachun5; Wang, Li1,2; Chen, Yiwen3; Yang, Ruilang3; Wu, Anshi6; Wei, Chang Wei6; Zhang, Xiangyang1,2
First AuthorTian, Yang
Correspondent Emailwcw0025@sina.com (c.w. wei) ; zhangxy@psych.ac.cn (x. zhang).
2020
Source PublicationSCHIZOPHRENIA RESEARCH
ISSN0920-9964
Subtypearticle
Volume215Pages:270-276
Contribution Rank1
Abstract

The prevalence of obesity in schizophrenia patients is high, especially in chronic and medicated patients. Few studies have explored the relationships between obesity, cognition and clinical correlates in patients with schizophrenia. This study was designed to assess the prevalence and clinical correlates of obesity and its relationship to cognitive impairment in Chinese patients with schizophrenia. We recruited 633 inpatients and collected clinical, demographic data and lipid parameters. The Positive and Negative Syndrome Scale (PANSS) and its five-factor model were adopted for psychopathological symptoms. The prevalence of comorbid obesity in schizophrenia patients was 16.4%. The plasma levels of glucose, triglyceride, low density lipoprotein (LDL), apolipoprotein B, and cholesterol were higher, but high density lipoprotein (HDL) levels were lower in obese patients than those in non-obese patients (all p <0.05). Furthermore, obese patients had lower PANSS negative symptom, cognitive factor and total scores than non-obese patients (all p <0.05). Correlation analysis showed a significant correlation between BMI and the following variables: age, marriage, gender, negative symptoms, general psychopathological symptoms, cognitive factor, PANSS total score, glucose, triglycerides, HDL, LDL, cholesterol and apolipoprotein B (all p <0.05). Further multiple regression showed that PANSS cognitive factor, PANSS total score, and triglyceride were important independent predictors of obesity. Our results indicate a high prevalence of obesity in Chinese patients with chronic schizophrenia. Multiple demographics, clinical variables, and lipid parameters are associated with obesity in schizophrenia. Moreover, obesity appears to be a protective factor for psychological symptoms. However, not having objective assessments for cognition in this study is a limitation. (C) 2019 Elsevier B.V. All rights reserved.

KeywordSchizophrenia Body mass index Obesity Clinical symptom Cognition
DOI10.1016/j.schres.2019.10.017
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Beijing Natural Science Foundation ; CAS Program
Funding ProjectNational Natural Science Foundation of China[81000509] ; National Natural Science Foundation of China[81771139] ; Beijing Natural Science Foundation[7194270] ; CAS Program
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000514823600038
PublisherELSEVIER
WOS KeywordBODY-MASS INDEX ; INDUCED WEIGHT-GAIN ; NEGATIVE SYNDROME SCALE ; ALL-CAUSE MORTALITY ; QUALITY-OF-LIFE ; RISK-FACTORS ; METABOLIC SYNDROME ; BIPOLAR DISORDER ; 5-FACTOR MODEL ; OVERWEIGHT
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30955
Collection中国科学院心理健康重点实验室
Corresponding AuthorWei, Chang Wei; Zhang, Xiangyang
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Third Peoples Hosp Ganzhou City, Dept Psychiat, Ganzhou, Jiangxi, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
6.Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Tian, Yang,Liu, Dianying,Wang, Dongmei,et al. Obesity in Chinese patients with chronic schizophrenia: Prevalence, clinical correlates and relationship with cognitive deficits[J]. SCHIZOPHRENIA RESEARCH,2020,215:270-276.
APA Tian, Yang.,Liu, Dianying.,Wang, Dongmei.,Wang, Jiesi.,Xu, Hang.,...&Zhang, Xiangyang.(2020).Obesity in Chinese patients with chronic schizophrenia: Prevalence, clinical correlates and relationship with cognitive deficits.SCHIZOPHRENIA RESEARCH,215,270-276.
MLA Tian, Yang,et al."Obesity in Chinese patients with chronic schizophrenia: Prevalence, clinical correlates and relationship with cognitive deficits".SCHIZOPHRENIA RESEARCH 215(2020):270-276.
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