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Placebo Effect on Modulating Empathic Pain: Reduced Activation in Posterior Insula
Zhao, Yili1,2; Liu, Ruixuan1,2; Zhang, Jianxin1,2; Luo, Jing3; Zhang, Wencai1,2
First AuthorZhao, Yili
Correspondent Emailwencai zhang zhangwc@psych.ac.cn
2020-01-31
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
Subtypearticle
Volume14Pages:11
Contribution Rank1
Abstract

Little evidence exists to confirm whether the sensory-related neural activity that occurs when observing others in pain is highly responsive to empathy for pain. From a perspective of intervention, the present study employed placebo manipulation with a transferable paradigm to explore whether the sensory regional activation that occurs when viewing pictures of others in pain could be modulated by the placebo effect. We first performed a screening behavioral experiment for selecting placebo responders and then entered them into a functional magnetic resonance (fMRI) experiment in which they were exposed to the same conditions as before. Participants were informed that it was equally possible to be assigned to the treatment group (placebo manipulation) or the no-treatment group (control); they all, in fact, received treatment and placebo effect would be detected by comparing placebo conditions and no-placebo control condition. Each participant experienced a phase of reinforcing placebo belief with pain in self and a phase of testing transferable placebo effect on empathy for pain. As a result, we found significant activation in sensory areas, including the posterior insula (PI) and the postcentral gyrus, and in the middle cingulate cortex while participants observed pictures of others in pain. More importantly, for the first time, we observed relieved activation in the PI modulated by the placebo effect only associated with pain pictures but not with no-pain pictures. This suggests that sensory activity in the PI might be involved in the processing for empathic pain. This new approach sheds light on research and applications in clinical settings.

Keywordempathy for pain picture-based paradigm posterior insula sensory area placebo effect
DOI10.3389/fnbeh.2020.00008
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Major Projects of the Beijing Municipal Science and Technology Commission
Funding ProjectNational Natural Science Foundation of China[31371131] ; National Natural Science Foundation of China[31100746] ; Major Projects of the Beijing Municipal Science and Technology Commission[D151100002315003]
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000514665500001
PublisherFRONTIERS MEDIA SA
WOS KeywordCORTICAL REPRESENTATION ; ANTERIOR CINGULATE ; OPIOID ACTIVITY ; NEURAL BASIS ; FMRI ; MECHANISMS ; EMOTION ; PERCEPTION ; EXPERIENCE ; ANALGESIA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30964
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Wencai
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Capital Normal Univ, Dept Psychol, Beijing Key Lab Learning & Cognit, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhao, Yili,Liu, Ruixuan,Zhang, Jianxin,et al. Placebo Effect on Modulating Empathic Pain: Reduced Activation in Posterior Insula[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2020,14:11.
APA Zhao, Yili,Liu, Ruixuan,Zhang, Jianxin,Luo, Jing,&Zhang, Wencai.(2020).Placebo Effect on Modulating Empathic Pain: Reduced Activation in Posterior Insula.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,14,11.
MLA Zhao, Yili,et al."Placebo Effect on Modulating Empathic Pain: Reduced Activation in Posterior Insula".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 14(2020):11.
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