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NRG3 contributes to cognitive deficits in chronic patients with schizophrenia
Li, Zezhi1; Liu, Lihua2; Lin, Wei2; Zhou, Yongjie3,4; Zhang, Guangya5; Du, Xiangdong5; Li, Yi3,4; Tang, Wei6,7; Zhang, Xiangyang8,9
First AuthorLi, Zezhi
Correspondent Emailkntw@163.com (w. tang) ; zhangxy@psych.ac.cn (x. zhang)
Contribution Rank8
Abstract

Background: Cognitive deficit is a fundamental trait of schizophrenia, but its mecwhanisms remain unknown. The neuregulin 3 (NRG3) gene, involving in neuronal function, has been considered to be associated with schizophrenia and cognition. However, no study has investigated the effects of NRG3 polymorphism on cognitive deficits in a large sample of the patients with schizophrenia. Methods: A total of 1112 schizophrenia patients and 423 controls were recruited and genotyped with NRG3 rs10748842. Among them, 864 patients and 403 controls were assessed for cognition through the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). SHEsis was applied and followed by logistic regression analysis. The models of analyses of covariance (ANCOVA) were constructed to examine the effects of NRG3 rs10748842 on cognitive deficits. Results: No differences in NRG3 rs10748842 allele and genotype were found between patients and controls (both p> 0.05). With the exception of Visuospatial/construction, the other RBANS scores were significantly lower in patients compared to controls after adjusting for gender and education (all p < 0.001). Interestingly, we found that NRG3 rs10748842 was associated with cognitive deficit in schizophrenia, showing that patients carrying C allele had lower attention and total scores than those with TT genotype (both p <0.05). Conclusion: NRG3 rs10748842 may not confer susceptibility to schizophrenia, but may be more closely associated with cognitive deficit, especially attention performance in chronic schizophrenia. (C) 2019 Elsevier B.V. All rights reserved.

KeywordSchizophrenia Cognition NRG3 Polymorphism
2020
Language英语
DOI10.1016/j.schres.2019.10.060
Source PublicationSCHIZOPHRENIA RESEARCH
ISSN0920-9964
Volume215Pages:134-139
Subtypearticle
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81401127] ; Beijing Municipal Natural Science Foundation[7132063] ; NARSAD Independent Investigator Grant[20314] ; Shanghai Municipal Commission of health and Family Planning Found[20134Y044] ; Shanghai Jiao Tong University Medical Engineering Foundation[YG2016MS48] ; Wuhan Municipal Health and Family Planning Commission[WX15C06] ; Wuhan Municipal Health and Family Planning Commission[WG12A00]
PublisherELSEVIER
WOS KeywordNEUREGULIN 3 NRG3 ; SYNAPTIC PLASTICITY ; BIPOLAR DISORDER ; RISK ; POLYMORPHISM ; SUSCEPTIBILITY ; IDENTIFICATION ; CONSEQUENCES ; ASSOCIATION ; PERFORMANCE
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000514823600020
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30982
Collection中国科学院心理健康重点实验室
Corresponding AuthorTang, Wei; Zhang, Xiangyang
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Neurol, Shanghai, Peoples R China
2.Qingdao Mental Hlth Ctr, Dept Psychiat, Qingdao, Peoples R China
3.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Wuhan, Peoples R China
5.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
6.Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Zhejiang, Peoples R China
7.Wenzhou Med Univ, Wenzhou, Zhejiang, Peoples R China
8.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
9.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Zezhi,Liu, Lihua,Lin, Wei,et al. NRG3 contributes to cognitive deficits in chronic patients with schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2020,215:134-139.
APA Li, Zezhi.,Liu, Lihua.,Lin, Wei.,Zhou, Yongjie.,Zhang, Guangya.,...&Zhang, Xiangyang.(2020).NRG3 contributes to cognitive deficits in chronic patients with schizophrenia.SCHIZOPHRENIA RESEARCH,215,134-139.
MLA Li, Zezhi,et al."NRG3 contributes to cognitive deficits in chronic patients with schizophrenia".SCHIZOPHRENIA RESEARCH 215(2020):134-139.
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