PSYCH OpenIR  > 中国科学院心理健康重点实验室
NRG3 contributes to cognitive deficits in chronic patients with schizophrenia
Li, Zezhi1; Liu, Lihua2; Lin, Wei2; Zhou, Yongjie3,4; Zhang, Guangya5; Du, Xiangdong5; Li, Yi3,4; Tang, Wei6,7; Zhang, Xiangyang8,9
First AuthorLi, Zezhi
Correspondent (w. tang) ; (x. zhang)
Contribution Rank8

Background: Cognitive deficit is a fundamental trait of schizophrenia, but its mecwhanisms remain unknown. The neuregulin 3 (NRG3) gene, involving in neuronal function, has been considered to be associated with schizophrenia and cognition. However, no study has investigated the effects of NRG3 polymorphism on cognitive deficits in a large sample of the patients with schizophrenia. Methods: A total of 1112 schizophrenia patients and 423 controls were recruited and genotyped with NRG3 rs10748842. Among them, 864 patients and 403 controls were assessed for cognition through the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). SHEsis was applied and followed by logistic regression analysis. The models of analyses of covariance (ANCOVA) were constructed to examine the effects of NRG3 rs10748842 on cognitive deficits. Results: No differences in NRG3 rs10748842 allele and genotype were found between patients and controls (both p> 0.05). With the exception of Visuospatial/construction, the other RBANS scores were significantly lower in patients compared to controls after adjusting for gender and education (all p < 0.001). Interestingly, we found that NRG3 rs10748842 was associated with cognitive deficit in schizophrenia, showing that patients carrying C allele had lower attention and total scores than those with TT genotype (both p <0.05). Conclusion: NRG3 rs10748842 may not confer susceptibility to schizophrenia, but may be more closely associated with cognitive deficit, especially attention performance in chronic schizophrenia. (C) 2019 Elsevier B.V. All rights reserved.

KeywordSchizophrenia Cognition NRG3 Polymorphism
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81401127] ; Beijing Municipal Natural Science Foundation[7132063] ; NARSAD Independent Investigator Grant[20314] ; Shanghai Municipal Commission of health and Family Planning Found[20134Y044] ; Shanghai Jiao Tong University Medical Engineering Foundation[YG2016MS48] ; Wuhan Municipal Health and Family Planning Commission[WX15C06] ; Wuhan Municipal Health and Family Planning Commission[WG12A00]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000514823600020
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorTang, Wei; Zhang, Xiangyang
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Neurol, Shanghai, Peoples R China
2.Qingdao Mental Hlth Ctr, Dept Psychiat, Qingdao, Peoples R China
3.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Wuhan, Peoples R China
5.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
6.Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Zhejiang, Peoples R China
7.Wenzhou Med Univ, Wenzhou, Zhejiang, Peoples R China
8.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
9.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Zezhi,Liu, Lihua,Lin, Wei,et al. NRG3 contributes to cognitive deficits in chronic patients with schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2020,215:134-139.
APA Li, Zezhi.,Liu, Lihua.,Lin, Wei.,Zhou, Yongjie.,Zhang, Guangya.,...&Zhang, Xiangyang.(2020).NRG3 contributes to cognitive deficits in chronic patients with schizophrenia.SCHIZOPHRENIA RESEARCH,215,134-139.
MLA Li, Zezhi,et al."NRG3 contributes to cognitive deficits in chronic patients with schizophrenia".SCHIZOPHRENIA RESEARCH 215(2020):134-139.
Files in This Item:
File Name/Size DocType Version Access License
NRG3 contributes to (242KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Zezhi]'s Articles
[Liu, Lihua]'s Articles
[Lin, Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Zezhi]'s Articles
[Liu, Lihua]'s Articles
[Lin, Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Zezhi]'s Articles
[Liu, Lihua]'s Articles
[Lin, Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.