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Association of cognitive and P50 suppression deficits in chronic patients with schizophrenia
Xia, Luyao1,2; Wang, Dongmei1,2; Wang, Jiesi1,2; Xu, Hang1,2; Huo, Lijuan1,2; Tian, Yang1,2; Dai, Qilong1,2; Wei, Shuochi1,2; Wang, Wenjia1,2; Zhang, Guangya3; Du, Xiangdong3; Jia, Qiufang3; Zhu, Xiaomin3; Wang, Li1,2; Tang, Wei4; Zhang, Xiang Yang1,2
First AuthorXia, Luyao
Correspondent Emailkntw@163.com
2020-03-01
Source PublicationCLINICAL NEUROPHYSIOLOGY
ISSN1388-2457
Subtypearticle
Volume131Issue:3Pages:725-733
Contribution Rank1
Abstract

Objective: Cognitive deficits are core symptoms of schizophrenia; however, their pathophysiological mechanisms are still unclear. A sensory gating deficit, as reflected by P50 suppression, has been repeatedly shown in schizophrenia patients, which may be associated with cognitive deficits in this disorder. The present study was to examine the relationship between the P50 suppression and cognitive deficits in patients with schizophrenia, which is still under-investigated. Method: We recruited 38 chronic schizophrenia patients and 32 matched healthy controls, and assessed their cognition with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and P50 suppression with the electroencephalography system. Results: The total and its 4 index scores (all p < 0.05) except for the visuospatial/ constructional index of RBANS were significantly lower in patients compared with healthy controls. However, only the language and attention passed Bonferroni corrections. Patients displayed a significantly higher P50 ratio, higher S2 amplitude, and lower S1 amplitude (all p < 0.05) than healthy controls. Interestingly, only in the patients, the S1 amplitude was associated with both language and attention, and the S2 amplitude with both visuospatial/ constructional and language (all p < 0.05), although all of these significances did not pass the Bonferroni corrections. The P50 ratio was not associated with any of the RBANS scores (all p > 0.05). Conclusions: Our results suggest the P50 suppression deficits in Chinese patients with schizophrenia, which may be associated with cognitive impairments of this illness. Moreover, the amplitude of S1 and the amplitude of S2 may be involved in the different cognitive domain deficits in schizophrenia patients. Significance: This study suggests that the P50 components may possibly be effective biomarkers for cognitive deficits in patients with schizophrenia. (C) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

KeywordSchizophrenia Cognition P50 Sensory gating Auditory evoked potential
DOI10.1016/j.clinph.2019.12.405
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China
Funding ProjectNational Natural Science Foundation of China[81371477]
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000513798800013
PublisherELSEVIER IRELAND LTD
WOS KeywordAUDITORY VERBAL HALLUCINATIONS ; VARIANTS CONFERRING RISK ; SENSORY GATING DEFICIT ; REPEATABLE BATTERY ; BIPOLAR DISORDER ; NEUROPHYSIOLOGICAL ENDOPHENOTYPES ; NEUROPSYCHOLOGICAL STATUS ; ACETYLCHOLINE-RECEPTOR ; PREPULSE INHIBITION ; SOCIAL COGNITION
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30985
Collection中国科学院心理健康重点实验室
Corresponding AuthorTang, Wei; Zhang, Xiang Yang
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Soochow Univ, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Peoples R China
4.Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou 325007, Zhejiang, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Xia, Luyao,Wang, Dongmei,Wang, Jiesi,et al. Association of cognitive and P50 suppression deficits in chronic patients with schizophrenia[J]. CLINICAL NEUROPHYSIOLOGY,2020,131(3):725-733.
APA Xia, Luyao.,Wang, Dongmei.,Wang, Jiesi.,Xu, Hang.,Huo, Lijuan.,...&Zhang, Xiang Yang.(2020).Association of cognitive and P50 suppression deficits in chronic patients with schizophrenia.CLINICAL NEUROPHYSIOLOGY,131(3),725-733.
MLA Xia, Luyao,et al."Association of cognitive and P50 suppression deficits in chronic patients with schizophrenia".CLINICAL NEUROPHYSIOLOGY 131.3(2020):725-733.
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