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Men and women differ in the neural basis of handwriting
Yang, Yang1,2,3; Tam, Fred4; Graham, Simon J.4,5; Sun, Guochen6; Li, Junjun1,2; Gu, Chanyuan1,2; Tao, Ran7; Wang, Nizhuan8; Bi, Hong-Yan1,2; Zuo, Zhentao9,10,11
Correspondent Emailyangyang@psych.ac.cn ; ztzuo@bcslab.ibp.ac.cn
2020-02-24
Source PublicationHUMAN BRAIN MAPPING
ISSN1065-9471
Subtypearticle
Pages14
Contribution Rank1
Abstract

There is an ongoing debate about whether, and to what extent, males differ from females in their language skills. In the case of handwriting, a composite language skill involving language and motor processes, behavioral observations consistently show robust sex differences but the mechanisms underlying the effect are unclear. Using functional magnetic resonance imaging (fMRI) in a copying task, the present study examined the neural basis of sex differences in handwriting in 53 healthy adults (ages 19-28, 27 males). Compared to females, males showed increased activation in the left posterior middle frontal gyrus (Exner's area), a region thought to support the conversion between orthographic and graphomotor codes. Functional connectivity between Exner's area and the right cerebellum was greater in males than in females. Furthermore, sex differences in brain activity related to handwriting were independent of language material. This study identifies a novel neural signature of sex differences in a hallmark of human behavior, and highlights the importance of considering sex as a factor in scientific research and clinical applications involving handwriting.

KeywordExner's area fMRI handwriting sex differences
DOI10.1002/hbm.24968
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Shenzhen Peacock Plan ; Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant ; CAS Key Laboratory of Behavioral Science, Institute of Psychology ; Shenzhen Fundamental Research Project ; Project of Six Talent Peaks of Jiangsu Province
Funding ProjectNational Natural Science Foundation of China[31800954] ; National Natural Science Foundation of China[31671155] ; National Natural Science Foundation of China[61701318] ; Shenzhen Peacock Plan[KQTD2015033016104926] ; Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant[2016ZT06S220] ; CAS Key Laboratory of Behavioral Science, Institute of Psychology ; Shenzhen Fundamental Research Project[JCYJ20170818110103216] ; Shenzhen Fundamental Research Project[JCYJ20170412164413575] ; Project of Six Talent Peaks of Jiangsu Province[SWYY-017]
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000515143500001
PublisherWILEY
WOS KeywordWRITTEN WORD PRODUCTION ; SEX-DIFFERENCES ; GENDER-DIFFERENCES ; ACADEMIC-ACHIEVEMENT ; BRAIN ACTIVATION ; FUNCTIONAL MRI ; LANGUAGE ; FMRI ; MOTOR ; METAANALYSIS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30994
Collection中国科学院行为科学重点实验室
Corresponding AuthorYang, Yang; Zuo, Zhentao
Affiliation1.Chinese Acad Sci, Inst Psychol, Ctr Brain Sci & Learning Difficulties, Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Shenzhen Inst Neurosci, Ctr Language, Shenzhen, Peoples R China
4.Sunnybrook Res Inst, Phys Sci Platform, Toronto, ON, Canada
5.Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
6.Chinese Peoples Liberat Army Gen Hosp, Dept Neurosurg, Med Ctr 1, Tianjin, Peoples R China
7.Hong Kong Polytech Univ, Dept Chinese & Bilingual Studies, Kowloon, Hong Kong, Peoples R China
8.Jiangsu Ocean Univ, Sch Comp Engn, Artificial Intelligence & Neuroinformat Engn ARIN, Lianyungang, Peoples R China
9.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
10.Chinese Acad Sci, Innovat Ctr Excellence Brain Sci, Beijing, Peoples R China
11.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yang,Tam, Fred,Graham, Simon J.,et al. Men and women differ in the neural basis of handwriting[J]. HUMAN BRAIN MAPPING,2020:14.
APA Yang, Yang.,Tam, Fred.,Graham, Simon J..,Sun, Guochen.,Li, Junjun.,...&Zuo, Zhentao.(2020).Men and women differ in the neural basis of handwriting.HUMAN BRAIN MAPPING,14.
MLA Yang, Yang,et al."Men and women differ in the neural basis of handwriting".HUMAN BRAIN MAPPING (2020):14.
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