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Transcutaneous Electrical Nerve Stimulation in Relieving Neuropathic Pain: Basic Mechanisms and Clinical Applications
Mokhtari, Tahmineh1,2; Ren, Qiaoyue1,2; Li, Nuo3; Wang, Faguang4; Bi, Yanzhi1,2; Hu, Li1,2,5
First AuthorMokhtari, Tahmineh
Correspondent Emailyanzhi bi biyz@psych.ac.cn
2020-02-18
Source PublicationCURRENT PAIN AND HEADACHE REPORTS
ISSN1531-3433
Subtypearticle
Volume24Issue:4Pages:14
QuartileQ2
Contribution Rank1
Abstract

Purpose of Review Transcutaneous electrical nerve stimulation (TENS) is widely used as a non-pharmacological approach for pain relief in a variety of clinical conditions. This manuscript aimed to review the basic mechanisms and clinical applications regarding the use of TENS for alleviating the peripheral (PNP) and central neuropathic pain (CNP). Recent Findings Basic studies on animal models showed that TENS could alleviate pain by modulating neurotransmitters and receptors in the stimulation site and its upper levels, including the spinal cord, brainstem, and brain. Besides, many clinical studies have investigated the efficacy of TENS in patients with CNP (caused by spinal cord injury, stroke, or multiple sclerosis) and PNP (induced by diabetes, cancer, or herpes zoster). Most clinical trials have demonstrated the efficacy of TENS in attenuating neuropathic pain and suggested that appropriate stimulation parameters (e.g., stimulation frequency and intensity) were critical to improving the analgesic effects of TENS. However, there are some conflicting findings related to the efficacy of TENS in relieving neuropathic pain. With optimized stimulation parameters, TENS would be effective in attenuating neuropathic pain. To obtain sufficient evidence to support the use of TENS in the clinic, researchers recommended performing multicenter clinical trials with optimized TENS protocols for the treatment of various CNP and PNP.

KeywordTranscutaneous electrical nerve stimulation Peripheral neuropathic pain Central neuropathic pain Neural mechanisms Analgesic effects
DOI10.1007/s11916-020-0846-1
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; CAS Key Laboratory of Mental Health, Institute of Psychology
Funding ProjectNational Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[31800926] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13506] ; China Postdoctoral Science Foundation[2018M640191] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y8CX351005] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2018ZG01]
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000517206800004
PublisherSPRINGER
WOS KeywordSPINAL-CORD-INJURY ; DIABETIC PERIPHERAL NEUROPATHY ; TENS-INDUCED ANTIHYPERALGESIA ; HIGH-FREQUENCY TENS ; MULTIPLE-SCLEROSIS ; NEUROGENIC HYPERALGESIA ; OPIOID RECEPTORS ; FLEXION REFLEX ; GRADING SYSTEM ; SHOULDER PAIN
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31000
Collection中国科学院心理健康重点实验室
Corresponding AuthorBi, Yanzhi
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Radio Res Agcy, Liaoning Inst Metrol, Shenyang, Peoples R China
4.Wenzhou Vocat & Tech Coll, Dept Elect & Elect Engn, Wenzhou, Peoples R China
5.Guangzhou Med Univ, Affiliated Hosp 2, State Key Clin Specialty Pain Med, Dept Pain Management, Guangzhou, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Mokhtari, Tahmineh,Ren, Qiaoyue,Li, Nuo,et al. Transcutaneous Electrical Nerve Stimulation in Relieving Neuropathic Pain: Basic Mechanisms and Clinical Applications[J]. CURRENT PAIN AND HEADACHE REPORTS,2020,24(4):14.
APA Mokhtari, Tahmineh,Ren, Qiaoyue,Li, Nuo,Wang, Faguang,Bi, Yanzhi,&Hu, Li.(2020).Transcutaneous Electrical Nerve Stimulation in Relieving Neuropathic Pain: Basic Mechanisms and Clinical Applications.CURRENT PAIN AND HEADACHE REPORTS,24(4),14.
MLA Mokhtari, Tahmineh,et al."Transcutaneous Electrical Nerve Stimulation in Relieving Neuropathic Pain: Basic Mechanisms and Clinical Applications".CURRENT PAIN AND HEADACHE REPORTS 24.4(2020):14.
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