PSYCH OpenIR  > 中国科学院心理健康重点实验室
P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery
Xia, Luyao1,2; Yuan, Lian3; Du, Xiang-Dong3; Wang, Dongmei1,2; Wang, Jiesi1,2; Xu, Hang1,2; Huo, Lijuan1,2; Tian, Yang1,2; Dai, Qilong1,2; Wei, Shuochi1,2; Wang, Wenjia1,2; Trihn, Tammy H.4; Alnatour, Omar I.4; Chen, Dachun5; Xiu, Meihong5; Wang, Li1,2; Yang, Mi6; Zhang, Xiang Yang1,2
First AuthorXia, Luyao
Correspondent Emailxiangdong-du@163.com (x.-d. du) ; zhangxy@psych.ac.cn (x.y. zhang)
2020
Source PublicationSCHIZOPHRENIA RESEARCH
ISSN0920-9964
Subtypearticle
Volume215Pages:105-112
Contribution Rank1
Abstract

Objective: Cognitive impairment is a core symptom of schizophrenia (SCZ); however, its pathophysio-logical mechanisms remain unclear. The sensory gating (SG) deficits reflected by P50 inhibition are recurring in SCZ, and this inhibition may be related to the cognitive deficits seen in these individuals. This study aimed to investigate the relationship between P50 inhibition and cognitive dysfunction in SCZ, which has not been fully investigated up to this point. Methods: A total of 270 individuals with chronic SCZ and 116 healthy controls were enrolled in the study. Psychopathology of SCZ was rated by the positive and negative syndrome scale (PANSS), while cognitive function and P50 inhibition of subjects were assessed by the MATRICS Consensus Cognitive Battery (MCCB) and the electroencephalography system. Results: The MCCB total and its 10 index scores were significantly lower in patients than those in healthy controls (all p <0.001). SCZ patients had a lower amplitude of S1, and higher P50 ratio than healthy controls (both p <0.01). However, there were no significant correlations between the P50 ratio and any of the PANSS total and its subscale scores in SCZ patients (all p > 0.05). Moreover, no correlation was found between the P50 components and the MCCB scores (all p> 0.05). Conclusions: Our findings suggest that the P50 inhibition deficits occur in Chinese individuals with SCZ, which may not be associated with their clinical symptoms and cognitive impairment. (C) 2019 Elsevier B.V. All rights reserved.

KeywordSchizophrenia Cognition P50 Sensory gating Auditory evoked potential
DOI10.1016/j.schres.2019.11.012
Indexed BySCI
Language英语
Funding OrganizationScience and Technology Department of Sichuan Province ; Key Diagnosis and treatment Program of Suzhou ; Suzhou Key Medical Center for Psychiatric Diseases ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Funding ProjectScience and Technology Department of Sichuan Province[2017JY0093] ; Key Diagnosis and treatment Program of Suzhou[LCZX201515] ; Key Diagnosis and treatment Program of Suzhou[LCZX201615] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000514823600016
PublisherELSEVIER
WOS KeywordRECEPTOR SUBUNIT GENE ; VARIANTS CONFERRING RISK ; SENSORY GATING DEFICIT ; NEUROCOGNITIVE DEFICITS ; ACETYLCHOLINE-RECEPTOR ; PREPULSE INHIBITION ; CIGARETTE-SMOKING ; NICOTINIC AGONIST ; SOCIAL COGNITION ; BIPOLAR DISORDER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31006
Collection中国科学院心理健康重点实验室
Corresponding AuthorDu, Xiang-Dong; Zhang, Xiang Yang
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, 11 Guangqian Rd, Suzhou 215008, Jiangsu, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Beijing HuiLongGuan Hosp, Beijing, Peoples R China
6.Fourth Peoples Hosp Chengdu, Dept Stomatol, Chengdu, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Xia, Luyao,Yuan, Lian,Du, Xiang-Dong,et al. P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery[J]. SCHIZOPHRENIA RESEARCH,2020,215:105-112.
APA Xia, Luyao.,Yuan, Lian.,Du, Xiang-Dong.,Wang, Dongmei.,Wang, Jiesi.,...&Zhang, Xiang Yang.(2020).P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery.SCHIZOPHRENIA RESEARCH,215,105-112.
MLA Xia, Luyao,et al."P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery".SCHIZOPHRENIA RESEARCH 215(2020):105-112.
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