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Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study
Du, Yi1; Zhao, Jingjie1; Wang, Yongzhi1; Han, Yu2; Deng, Ligang3; Jia, Hongxiao4; Zhou, Yuan5,6; Su, Joyce7; Li, Li1
First AuthorDu, Yi
Correspondent Emailli li; lili@ccmu.edu.cn
Contribution Rank5
Abstract

Major depressive disorder (MDD), especially combined with anxiety, has a high incidence and low detection rate in China. Literature has shown that patients under major depression with anxiety (MDA) are more likely to nominate a somatic, rather than psychological, symptom as their presenting complaint. In the theory of Traditional Chinese Medicine (TCM), clinical symptoms of MDD patients are mainly categorized into two different syndrome patterns: Deficiency and Excess. We intend to use resting-state functional magnetic resonance imaging (rs-fMRI) to investigate their brain functional differences and hopefully to find their brain function mechanism. For our research, 42 drug-naive MDA patients were divided into two groups (21 for Deficiency and 21 for Excess), with an additional 19 unaffected participants in the normal control (NC) group. We took Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA), and brain fMRI scan for each group and analyzed the data. We first used Degree Centrality (DC) to map the functional differences in brain regions, utilized these regions as seed points, and used a seed-based functional connectivity (FC) analysis to identify the specific functional connection between groups. The Deficiency group was found to have higher HAMD scores, HAMA scores, and HAMD somatic factor than the Excess group. In the DC analysis, significant decreases were found in the right precuneus of both the Deficiency and Excess groups compared to the NC group. In the FC analysis, the right precuneus showed significant decreased network connectivity with the bilateral cuneus, as well as the right lingual gyrus in the Deficiency group when compared to the NC group and the Excess group. Through our research, it was found that precuneus dysfunction may have a relationship with MDA and Deficiency patients have more severe physical and emotional symptoms, and we realized that a larger sample size and multiple brain mode observations were needed in further research.

2020-02-18
Language英语
DOI10.1155/2020/7504917
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
Volume2020Pages:9
Subtypearticle
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81673737] ; Beijing Natural Science Foundation[7172063] ; Beijing Administration of Traditional Chinese Medicine[JJ2018-51] ; Beijing Municipal Administration of Hospitals Incubating Program[PZ2017024] ; Beijing Health System Training Program for High Level Technique Talents[2014-3-001]
PublisherHINDAWI LTD
WOS KeywordDEFAULT MODE NETWORK ; MEDICATION-NAIVE ; REGIONAL HOMOGENEITY ; PREFRONTAL CORTEX ; PRECUNEUS ; CONNECTIVITY ; 1ST-EPISODE ; DISORDER ; SCALE ; SEVERITY
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000518961000001
QuartileQ3
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31374
Collection中国科学院行为科学重点实验室
Corresponding AuthorLi, Li
Affiliation1.Capital Med Univ, Beijing Friendship Hosp, Dept Tradit Chinese Med, Beijing, Peoples R China
2.Your Hlth & Wellness Int Med Clin, Beijing, Peoples R China
3.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, Beijing, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Dept Psychiat, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Case Western Reserve Univ, Dept Biochem, Cleveland, OH 44106 USA
Recommended Citation
GB/T 7714
Du, Yi,Zhao, Jingjie,Wang, Yongzhi,et al. Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,2020:9.
APA Du, Yi.,Zhao, Jingjie.,Wang, Yongzhi.,Han, Yu.,Deng, Ligang.,...&Li, Li.(2020).Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,9.
MLA Du, Yi,et al."Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020(2020):9.
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