Institutional Repository of Key Laboratory of Behavioral Science, CAS
Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole-brain resting-state effective connectivity analysis | |
Hua, Minghui1,2; Peng, Yanmin1,2; Zhou, Yuan3,4,5; Qin, Wen6,7; Yu, Chunshui1,2,6,7,8; Liang, Meng1,2 | |
摘要 | Background: Numerous neuroimaging studies have revealed that schizophrenia was characterized by widespread dysconnection among brain regions during rest measured by functional connectivity (FC). In contrast with FC, effective connectivity (EC) provides information about directionality of brain connections and is thus valuable in mechanistic investigation of schizophrenic brain. However, a systematic characterization of whole-brain resting-state EC (rsEC) and how it captures different information compared with resting-state FC (rsFC) in schizophrenia are still lacking. Aims: To systematically characterize the abnormalities of rsEC, compared with rsFC, in schizophrenia, and to test its discriminative power as a neuroimaging marker for schizophrenia diagnosis. Method: Whole-brain rsEC and rsFC networks were constructed using resting-state fMRI data and compared between 103 patients with schizophrenia and 110 healthy participants. Pattern classifications between patients and controls based on whole-brain rsEC and rsFC were further performed using multivariate pattern analysis. Results: We identified 17 rsEC significantly disrupted (mostly decreased) in patients, among which all were associated with the thalamus and 15 were from limbic areas (including hippocampus, parahippocampus and cingulate cortex) to the thalamus. In contrast, abnormal rsFC were widely distributed in the whole brain. The classification accuracies for distinguishing patients and controls using whole-brain rsEC and rsFC patterns were 78.6% and 82.7%, respectively, and was further improved to 84.5% when combining rsEC and rsFC. Conclusions: Schizophrenia is featured by disrupted 'limbic areas-to-thalamus' rsEC, in contrast with diffusively altered rsFC. Moreover, both rsEC and rsFC contain valuable and complementary information which may be used as diagnostic markers for schizophrenia. |
关键词 | Functional MRI Functional connectivity Multivariate pattern analysis Granger causality Pattern classification |
2020-04-20 | |
语种 | 英语 |
DOI | 10.1016/j.pnpbp.2019.109837 |
发表期刊 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY |
ISSN | 0278-5846 |
卷号 | 99页码:10 |
收录类别 | SCI |
资助项目 | National Key R&D Program of China[2017YFC0909201] ; National Key R&D Program of China[2018YFC1314300] ; National Natural Science Foundation of China[81571659] ; National Natural Science Foundation of China[81971694] ; National Natural Science Foundation of China[81971599] ; National Natural Science Foundation of China[81771818] ; Tianjin Key Technology RD Program[17ZXMFSY00090] ; Natural Science Foundation of Tianjin[19JCYBJC25100] |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS关键词 | FUNCTIONAL CONNECTIVITY ; GRANGER CAUSALITY ; DEFAULT MODE ; CLASSIFICATION ; ABNORMALITIES ; NETWORK ; MATTER ; MEMORY ; RISK |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
WOS类目 | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
WOS记录号 | WOS:000518756400012 |
资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Tianjin Key Technology RD Program ; Natural Science Foundation of Tianjin |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31377 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Liang, Meng |
作者单位 | 1.Tianjin Med Univ, Sch Med Imaging, 1 Guangdong Rd, Tianjin 300203, Peoples R China 2.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Behav Sci, Inst Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China 7.Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China 8.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Hua, Minghui,Peng, Yanmin,Zhou, Yuan,et al. Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole-brain resting-state effective connectivity analysis[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2020,99:10. |
APA | Hua, Minghui,Peng, Yanmin,Zhou, Yuan,Qin, Wen,Yu, Chunshui,&Liang, Meng.(2020).Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole-brain resting-state effective connectivity analysis.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,99,10. |
MLA | Hua, Minghui,et al."Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole-brain resting-state effective connectivity analysis".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 99(2020):10. |
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