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Altered brain white matter microstructural asymmetry in children with ADHD
Wu, Zhao-Min1,2,3,4,5; Wang, Peng2,3; Yang, Li2,3; Liu, Lu2,3; Sun, Li2,3; An, Li2,3; Cao, Qing-Jiu2,3; Chan, Raymond C. K.6,7; Yang, Bin-Rang1; Wang, Yu-Feng2,3
First AuthorWu, Zhao-Min
Correspondent Emailzhaomin.wu@foxmail.com (z.-m. wu) ; ,wangyf@bjmu.edu.cn (y.-f. wang)
Contribution Rank5
Abstract

Objectives: We aimed to examine brain white matter integrity in children with ADHD. Methods: In a cohort of children with ADHD (n = 83) and healthy controls (n = 122), we used tract-based spatial statistics on Diffusion Tensor Imaging (DTI) data to obtain the mean fractional anisotropy (FA) in 40 bilateral regions of interest (ROIs). Lateralization Index (LI) was calculated. The difference in LI between groups and correlations between the LI of each ROI and ADHD symptom scores as well as cognitive function were examined. Results: Children with ADHD had significantly greater LI at the posterior thalamic radiation (PTR) compared with healthy controls (mean LI in ADHD = 0.0096; in Control = 0.0044, p = 0.0143), and LI of the external capsule (EC) was significantly correlated with inattention symptoms in both groups (beta = - 0.00059, p = 0.0181). LI of the PTR was significantly correlated with inhibitory function in healthy controls (beta = - 0.0008510, p = 0.0248), but not in children with ADHD. Conclusion: We found increased brain white matter asymmetry (leftward) in children with ADHD compared with healthy controls at the posterior thalamic radiation. Leftward lateralization of FA values at the external capsule was negatively correlated with ADHD symptoms in both children with ADHD and healthy controls.

KeywordWhite matter Asymmetry ADHD
2020-03-01
Language英语
DOI10.1016/j.psychres.2020.112817
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
Volume285Pages:6
Subtypearticle
Indexed BySCI
Funding ProjectSanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth hospital[SZSM201612036] ; National Basic Research Program of China (973 program)[2014CB846104]
PublisherELSEVIER IRELAND LTD
WOS KeywordDEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; STRUCTURAL CONNECTIVITY ; SPATIAL STATISTICS ; VOLUME
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000518866900019
QuartileQ2
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31386
Collection中国科学院心理健康重点实验室
Corresponding AuthorWu, Zhao-Min; Wang, Yu-Feng
Affiliation1.Shenzhen Childrens Hosp, Shenzhen 518000, Peoples R China
2.Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands
5.Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wu, Zhao-Min,Wang, Peng,Yang, Li,et al. Altered brain white matter microstructural asymmetry in children with ADHD[J]. PSYCHIATRY RESEARCH,2020,285:6.
APA Wu, Zhao-Min.,Wang, Peng.,Yang, Li.,Liu, Lu.,Sun, Li.,...&Wang, Yu-Feng.(2020).Altered brain white matter microstructural asymmetry in children with ADHD.PSYCHIATRY RESEARCH,285,6.
MLA Wu, Zhao-Min,et al."Altered brain white matter microstructural asymmetry in children with ADHD".PSYCHIATRY RESEARCH 285(2020):6.
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